Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M.C. Abreu, M. Alimi, C. Baglin, A. Baldisseri, A. Baldit, et al.. Transverse momentum of dimuons produced in p-Cu, p-U, ^{16}O-Cu, ^{16}O-U and ^{32}S-U collisions at 200 GeV per nucleon. Rencontres de Moriond 26, Mar 1991, Les Arcs, France. ⟨in2p3-00010851⟩
  • M.C. Abreu, M. Alimi, C. Baglin, A. Baldisseri, A. Baldit, et al.. Mesons production in p+U, O+U and S+U interactions at 200 GeV/nucleon. Rencontres de Moriond 26, Mar 1991, Les Arcs, France. pp.365. ⟨in2p3-00010852⟩
  • G. Bassompierre, D. Boget, J. Dufournaud, M. Gouanere, Murielle Richard, et al.. Darmstadton hunting in gamma-cristal interaction. Rencontre de Moriond 26, Jan 1991, Les Arcs, France. pp.409-414. ⟨in2p3-00018220⟩
  • X.C. Hu, B. Chambon, B. Cheynis, A. Demeyer, D. Drain, et al.. Central collisions for the ^{32} s(30 A MeV) + Ag system in the 4\pi Amphora detection array. International Winter Meeting On Nuclear Physics 29, Jan 1991, Bormio, Italy. pp.214-223. ⟨in2p3-00013348⟩
  • P. Decowski, E. Gierlik, P.F. Box, K.A. Griffioen, R. Kamermans, et al.. Entrance channel effects in the ^{28}Si + ^{28}Si reaction. International Winter Meeting on Nuclear Physics.29, Jan 1991, Bormio, Italy. pp.585-602. ⟨in2p3-00004248⟩
  • J.A. Ruiz, G. Nebbia, D. Fabris, G. Viesti, R.H. Burch, et al.. Incomplete fusion and cluster production in heavy-ion collisions at 30 MeV/amu. International Winter Meeting on Nuclear Physics.29, Jan 1991, Bormio, Italy. pp.176-192. ⟨in2p3-00001981⟩
  • P. Desesquelles, A.J. Cole, A. Giorni, D. Heuer, A. Lleres, et al.. Measurement and analysis of charge partitions in nuclear disassembly. International Winter Meeting On Nuclear Physics 29, Jan 1991, Bormio, Italy. pp.49-56. ⟨in2p3-00013377⟩
  • M. Farizon, B. Farizon-Mazuy, N.V. de Castro Faria, H. Chermette. Ab initio structure calculations of hydrogen ionic clusters. Chemical Physics Letters, 1991, 177, pp.451-457. ⟨in2p3-00002495⟩
  • J. Jaenicke, G. Bertsch, G. Chanfray, H. Esbensen, P. Schuck. Quasi-elastic (p.p') reactions in simplified response models. Nuclear Physics A, 1991, 524, pp.768-776. ⟨10.1016/0375-9474(91)90273-9⟩. ⟨in2p3-00002176⟩
  • K. Bellafrouh, F.M. Michel-Calendini, H. Chermette. Superhyperfine constants and optical spectra for mn${^2+} ions in cubic fluoride lattices through a molecular orbital model. Radiation Effects and Defects in Solids, 1991, 119/121, pp.741-746. ⟨in2p3-00013241⟩

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