Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • I. Romanski, I. Berkes, D.E. Brown, M. de Jésus, R. Eder, et al.. Time resolved and time integral on line nuclear orientation measurements of neutron deficient Hg Au Pt Ir nuclei. International Conference on Online Nuclear Orientation : OLNO 2, Oct 1991, Oak Ridge, United States. pp.457-470. ⟨in2p3-00013106⟩
  • A. Astier, R. Béraud, A. Bouldjedri, R. Duffait, A. Emsallem, et al.. Status report of the Sara Igisol used in the study of the ^{238} U(\alpha 40 MeV-F) reaction. International Conference On Electromagnetic Isotope Separators And Techniques Related To Their Applications 12, Sep 1991, Sendai, Japan. pp.233-240. ⟨in2p3-00007624⟩
  • M. Kibler. Symmetry adaptation in two-photon spectroscopy. International School on Excited States of Transition Elements 2, Sep 1991, Wroclaw-Karpacz, Poland. pp.139-148. ⟨in2p3-00003190⟩
  • M. Kibler, M. Daoud. Symmetry adaptation and two photon spectroscopy of ions in molecular or solid state finite symmetry. Vth Workshop on Symmetry Methods in Physics, Jul 1991, Obninsk, Russia. pp.37-49. ⟨in2p3-00003193⟩
  • J.B. Natowitz, M. Gonin, K. Hagel, R. Wada, S. Shlomo, et al.. Dynamical and statistical properties of hot nuclei. International Conference On Nucleus-Nucleus Collisions 4, Jun 1991, Kanazawa, Japan. pp.263C-274C. ⟨in2p3-00013242⟩
  • M. Ericson. A decay in nuclei. International Workshop on Pions in Nuclei, Jun 1991, Penyscola (Castellon), Spain. ⟨in2p3-00007375⟩
  • G. Chanfray, P. Schuck. Dilepton production and the pi-pi mass distribution in the rho and sigma meson channels in nuclei. International Workshop on Pions in Nuclei, Jun 1991, Penyscola, Spain. pp.140-146. ⟨in2p3-00003047⟩
  • J-M. Covolan, P. Desgrolard, M. Giffon, E. Predazzi. The Pomeron vindicated. International Conference On Elastic And Diffractive Scattering Blois Workshop On Elastic And Diffractive Scattering 4, May 1991, La Biodola,Elba, Italy. pp.86-90. ⟨in2p3-00010662⟩
  • M.C. Abreu, C. Baglin, A. Baldisseri, A. Baldit, M. Bedjidian, et al.. Muon pair production in heavy ion interactions at 200 GeVC per nucleon. Quark Matter 91, Apr 1991, Gatlinburg, United States. pp.209c-222c. ⟨in2p3-00022984⟩
  • D. Drain. First results obtained with the 4\pi \amphora detection array. European Biennial Workshop On Nuclear Physics 1, Mar 1991, Megeve, France. pp.52-71. ⟨in2p3-00004082⟩

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