Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Constraints on anomalous HVV couplings from the production of Higgs bosons decaying to \tau lepton pairs. Phys.Rev.D, 2019, 100 (11), pp.112002. ⟨10.1103/PhysRevD.100.112002⟩. ⟨hal-02088599⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for an exotic decay of the Higgs boson to a pair of light pseudoscalars in the final state with two muons and two b quarks in pp collisions at 13 TeV. Phys.Lett.B, 2019, 795, pp.398-423. ⟨10.1016/j.physletb.2019.06.021⟩. ⟨hal-01975266⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for supersymmetry using Higgs boson to diphoton decays at \sqrt{s} = 13 TeV. JHEP, 2019, 11, pp.109. ⟨10.1007/JHEP11(2019)109⟩. ⟨hal-02302953⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for narrow H\gamma resonances in proton-proton collisions at \sqrt{s} = 13 TeV. Phys.Rev.Lett., 2019, 122 (8), pp.081804. ⟨10.1103/PhysRevLett.122.081804⟩. ⟨hal-01861881⟩
    • Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for dark matter particles produced in association with a top quark pair at \sqrt{s} = 13 TeV. Phys.Rev.Lett., 2019, 122 (1), pp.011803. ⟨10.1103/PhysRevLett.122.011803⟩. ⟨hal-01861918⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for a W′ boson decaying to a vector-like quark and a top or bottom quark in the all-jets final state. JHEP, 2019, 03, pp.127. ⟨10.1007/JHEP03(2019)127⟩. ⟨hal-01945206⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Probing the chiral magnetic wave in pPb and PbPb collisions at \sqrt {s_{NN}} =5.02TeV using charge-dependent azimuthal anisotropies. Phys.Rev.C, 2019, 100 (6), pp.064908. ⟨10.1103/PhysRevC.100.064908⟩. ⟨hal-02410792⟩
    • Mattia Fontana. Tests and characterization of gamma cameras for medical applications. Medical Physics [physics.med-ph]. Université de Lyon, 2018. English. ⟨NNT : 2018LYSE1285⟩. ⟨tel-02017992v2⟩
    • Dominique Gibert, Yves Le Gonidec, Marina Rosas-Carbajal, Jean de Bremond d'Ars, Bruno Carlus, et al.. Abrupt Changes of Hydrothermal Activity in a lava Dome Detected by Combined Seismic and Muon Monitoring. American Geophysical Union 2018, Fall Meeting, Dec 2018, Washington, United States. , pp.NS23B-0701, 2018. ⟨insu-01927663⟩
    • Jacques Marteau, Marina Rosas-Carbajal, Dominique Gibert, Bruno Carlus, Jean-Christophe Ianigro, et al.. Applied muography : from volcanology to archaelogy with a mobile muon detector (DIAPHANE / ARCHé). American Geophysical Union 2018, Fall Meeting, Dec 2018, Washington, United States. , pp.NS23B-0705, 2018. ⟨insu-01927696⟩

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