Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. de Jésus. Moments nucléaires de noyaux de transition près des couches Z = 40 et Z = 82. Cosmology and Extra-Galactic Astrophysics [astro-ph.CO]. Université Claude Bernard - Lyon I, 1992. English. ⟨NNT : ⟩. ⟨in2p3-00013297⟩
  • D. Gelé. Recherche du boson de Higgs standard par le canal e^+e^- \rightarrow He^+ e dans l'experience L3. High Energy Physics - Experiment [hep-ex]. Université Claude Bernard - Lyon I, 1992. English. ⟨NNT : ⟩. ⟨in2p3-00023106⟩
  • G. Chanfray, P. Schuck. Rho meson mass spectrum in dense matter. International Workshop On Dynamical Fluctuations And Correlations In Nuclear Collisions, Mar 1992, Aussois, France. pp.271-276. ⟨in2p3-00001000⟩
  • T. Ethvignot, N.N. Ajitanand, C.J. Gelderloos, J.M. Alexander, E. Bauge, et al.. Correlations between pairs of particles and fragments from ^{40}Ar reactions of 7-34 A MeV. International Workshop On Dynamical Fluctuations And Correlations In Nuclear Collisions, Mar 1992, Aussois, France. pp.347-362. ⟨in2p3-00013058⟩
  • M. Kibler, T. Negadi. On quantum groups and their potential use in mathematical chemistry. Journal of Mathematical Chemistry, 1992, 11, pp.13-25. ⟨in2p3-00003103⟩
  • M. Benmansour. Application de l'analyse par reactions nucleaires a l'etude de l'adsorption de l'hydrogene et du benzene sur des monocristaux de nickel et d'alliage Pt_{50} Ni_{50}. Nuclear Experiment [nucl-ex]. Université Claude Bernard - Lyon I, 1992. English. ⟨NNT : ⟩. ⟨in2p3-00013299⟩
  • N. Idrissi, A. Gizon, J. Genevey, P. Paris, V. Barci, et al.. Conversion electron measurements in the ^{124}La \beta decay spin and parity assignments in ^{124}Ba. Zeitschrift für Physik. A, Atoms and Nuclei, 1992, 341, pp.427-433. ⟨10.1007/BF01301386⟩. ⟨in2p3-00007606⟩
  • P. Abreu, W. Adam, F. Adami, T. Adye, T. Akesson, et al.. Multiplicity dependence of mean transverse momentum in e^+e^- annihilations at LEP energies. Physics Letters B, 1992, 276, pp.254-262. ⟨10.1016/0370-2693(92)90573-M⟩. ⟨in2p3-00005103⟩
  • P. Abreu, W. Adam, F. Adami, T. Adye, T. Akesson, et al.. Search for excited charged leptons in Z^0 decays. Zeitschrift für Physik. C, Particles and Fields, 1992, 53, pp.41-49. ⟨in2p3-00003576⟩
  • P. Abreu, W. Adam, F. Adami, T. Adye, E. Agasi, et al.. A study of the decays of tau leptons produced on the Z resonance at LEP. Zeitschrift für Physik. C, Particles and Fields, 1992, 55, pp.555-567. ⟨10.1007/BF01561293⟩. ⟨in2p3-00001241⟩

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