Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Vincent Breton, H. Fonvieille, B. Frois, R. van de Vyver, G. Smadja, et al.. Matiere hadronique ou... aujourd'hui et demain avec des electrons. Ecole Joliot-Curie De Physique Nucleaire. 11, Sep 1992, Maubuisson, France. pp.1-368. ⟨in2p3-00007772⟩
  • X. Artru. Rayonnement de canalisation et phénomènes de champ fort. École thématique. Ecole Joliot Curie "Matière hadronique ou..aujourd'hui et demain avec des électrons", Maubuisson, (France), du 14-19 septembre 1992 : 11ème session, 1992. ⟨cel-00648094⟩
  • G. Smadja. Introduction à la diffusion inélastique des leptons. École thématique. Ecole Joliot Curie "Matière hadronique ou..aujourd'hui et demain avec des électrons", Maubuisson, (France), du 14-19 septembre 1992 : 11ème session, 1992. ⟨cel-00648077⟩
  • M. Giffon. Odderon: a myth or a reality?. Workshop on Elastic and Diffractive Scattering, Sep 1992, Kiev, Ukraine. ⟨in2p3-00010617⟩
  • M. Kibler. Introduction to quantum algebras. International School Of Theoretical Physics Symmetry And Structural Properties Of Condensed Matter 2, Aug 1992, Poznan, Poland. pp.1-24. ⟨in2p3-00002501⟩
  • Yu.F. Smirnov, M. Kibler. Some aspects of q-boson calculus. Symposium On Symmetries In Sciences From The Rotation Group To Quantum Algebras Held At The Cloister Mehrerau 6, Aug 1992, Bregenz, Austria. pp.1-14. ⟨in2p3-00002503⟩
  • J. Genevey, A. Gizon, J. Inchaouh, S. Andre, V. Barci, et al.. A new 5.7 s isomer in ^{131}Pr and low-energy intrinsic states in A=131-129-127 Pr and Ce isotopes. International Conference on Nuclei Far from Stability 6 International Conference on Atomic Masses and Fundamental Constants 9, Jul 1992, Bernkastel-Kues, Germany. pp.671-673. ⟨in2p3-00009620⟩
  • F. Ibrahim, D. Hojman, C. Bourgeois, J. Davidson, M. Davidson, et al.. Odd-odd nuclei around A=184. International Conference on Nuclei Far From Stability 6 International Conference on Atomic Masses and Fundamental Constants 9, Jul 1992, Bernkastel-Kues, Germany. pp.731-733. ⟨in2p3-00013092⟩
  • M. Bedjidian, D. Contardo, I. Evangelou, M. Geijsberts, F.G. Hartjes, et al.. Central tracking with micro strip gas chambers in CMS. International Conference on Advanced Technology and Particle Physics 3, Jun 1992, Como, Italy. pp.189-201. ⟨in2p3-00007609⟩
  • F. Garrido, A. Benyagoub, A. Chamberod, J.C. Dran, A. Dunlop, et al.. New insight on the ion beam-induced plastic deformation in amorphous alloy by marker experiments. International Symposium On Swift Heavy Ions In Matter 2, May 1992, Bensheim/Darmstadt, Germany. pp.129-132. ⟨in2p3-00013038⟩

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