Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • D. Benchekroun, F. Benrachi, B. Chambon, B. Cheynis, D. Drain, et al.. Scintillating gas proportional phoswiches. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1993, 335, pp.503-508. ⟨10.1016/0168-9002(93)91236-G⟩. ⟨in2p3-00003540⟩
  • T. Ethvignot, N.N. Ajitanand, J.M. Alexander, A. Elmaani, C.J. Gelderloos, et al.. Transverse momentum correlations between particle-particle pairs as a probe of effective emitter mass : 40Ar+natAg (E/A=7, 17, 27, and 34 MeV). Physical Review C, 1993, 47, pp.2099-2106. ⟨10.1103/PhysRevC.47.2099⟩. ⟨in2p3-00007602⟩
  • P.J. Dagnall, C.W. Beausang, P. Fallon, P.D. Forsyth, E.S. Paul, et al.. Coexistence of collective oblate and superdeformed prolate shapes in ^{196}Pb. Journal of Physics G: Nuclear and Particle Physics, 1993, 19, pp.465-470. ⟨in2p3-00007597⟩
  • M.J. Gaillard, A. Schempp, H.O. Moser, H. Deitinghoff, R. Genre, et al.. First high energy hydrogen cluster beams a new facility at IPNL France. Zeitschrift für Physik. D, Atoms, molecules and clusters, 1993, 26(supp), pp.347-349. ⟨in2p3-00013027⟩
  • X. Artru. Probes of parton transversity. International Symposium On High Energy Spin Physics 10, Nov 1992, Nagoya, Japan. pp.605-608. ⟨in2p3-00000902⟩
  • F. Hannachi, C. Schuck, G. Bastin, I. Deloncle, B. Gall, et al.. Study of the superdeformed band in ^{194}Pb and ^{192}Hg with eurogam. International Symposium on Rapidly Rotating Nuclei 21, Oct 1992, Tokyo, Japan. pp.75C-82C. ⟨in2p3-00007601⟩
  • K. Bencheikh, P. Quentin, J. Bartel, J. Meyer. A semiclassical description of rapidly rotating nuclei. International Symposium On Rapidly Rotating Nuclei 21, Oct 1992, Tokyo, Japan. pp.459C-468C. ⟨in2p3-00014385⟩
  • F. Malek, Vincent Breton, J.-Y. Grossiord, A. Guichard, G. Chanfray, et al.. A di-muon spectrometer(dms) for the study of charmonium production. Workshop On European Electron Facility, Oct 1992, Mainz, Germany. pp.541-551. ⟨in2p3-00009716⟩
  • P.Y. Bertin, J. Berthot, Vincent Breton, G. Audit, O. Benhar, et al.. Photo and electro production of strangeness and charm in hadronic matter. Workshop On European Electron Facility, Oct 1992, Mainz, Germany. pp.273-329. ⟨in2p3-00015205⟩
  • G. Smadja. Introduction à la diffusion inélastique des leptons. École thématique. Ecole Joliot Curie "Matière hadronique ou..aujourd'hui et demain avec des électrons", Maubuisson, (France), du 14-19 septembre 1992 : 11ème session, 1992. ⟨cel-00648077⟩

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