Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for top quark partners with charge 5/3 in the same-sign dilepton and single-lepton final states in proton-proton collisions at \sqrt{s}=13 TeV. JHEP, 2019, 03, pp.082. ⟨10.1007/JHEP03(2019)082⟩. ⟨hal-01902957⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for single production of vector-like quarks decaying to a top quark and a W boson in proton-proton collisions at \sqrt{s} = 13 TeV. Eur.Phys.J.C, 2019, 79, pp.90. ⟨10.1140/epjc/s10052-019-6556-3⟩. ⟨hal-01890849⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for physics beyond the Standard Model in events with overlapping photons and jets. Phys.Rev.Lett., 2019, 123 (24), pp.241801. ⟨10.1103/PhysRevLett.123.241801⟩. ⟨hal-02277910⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for Higgs and Z boson decays to J/ψ or Y pairs in the four-muon final state in proton-proton collisions at s=13TeV. Phys.Lett.B, 2019, 797, pp.134811. ⟨10.1016/j.physletb.2019.134811⟩. ⟨hal-02154210⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurements of the pp \to WZ inclusive and differential production cross section and constraints on charged anomalous triple gauge couplings at \sqrt{s} = 13 TeV. JHEP, 2019, 04, pp.122. ⟨10.1007/JHEP04(2019)122⟩. ⟨hal-01999882⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for a standard model-like Higgs boson in the mass range between 70 and 110 GeV in the diphoton final state in proton-proton collisions at \sqrt{s}= 8 and 13 TeV. Phys.Lett.B, 2019, 793, pp.320-347. ⟨10.1016/j.physletb.2019.03.064⟩. ⟨hal-01945227⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for the production of four top quarks in the single-lepton and opposite-sign dilepton final states in proton-proton collisions at \sqrt{s} = 13 TeV. JHEP, 2019, 11, pp.082. ⟨10.1007/JHEP11(2019)082⟩. ⟨hal-02165586⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of the top quark polarization and \mathrm{t\bar{t}} spin correlations using dilepton final states in proton-proton collisions at \sqrt{s} = 13 TeV. Phys.Rev.D, 2019, 100 (7), pp.072002. ⟨10.1103/PhysRevD.100.072002⟩. ⟨hal-02192539⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for supersymmetry in events with a photon, jets, \mathrm {b} -jets, and missing transverse momentum in proton–proton collisions at 13 \,\text {Te}\text {V}. Eur.Phys.J.C, 2019, 79 (5), pp.444. ⟨10.1140/epjc/s10052-019-6926-x⟩. ⟨hal-02009800⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for the associated production of the Higgs boson and a vector boson in proton-proton collisions at \sqrt{s}= 13 TeV via Higgs boson decays to \tau leptons. JHEP, 2019, 06, pp.093. ⟨10.1007/JHEP06(2019)093⟩. ⟨hal-01885935⟩

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