Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • I. Laktineh, W.M. Alberico, J. Delorme, M. Ericson. Coherent photoproduction of neutral pions in nuclei as a detector of nuclear pionic modes. Nuclear Physics A, 1993, 555, pp.237-248. ⟨in2p3-00000622⟩
  • G. Chanfray, J. Delorme, M. Ericson, A. Molinari. Quasi elastic delta excitation in the charge response of the nucleus. Nuclear Physics A, 1993, 556, pp.439-452. ⟨in2p3-00000642⟩
  • Malcolm J Joyce, John Francis Sharpey-Schafer, P.J. Twin, C.W. Beausang, D.M. Cullen, et al.. First measurement of magnetic properties in a superdeformed nucleus: 193Hg. Physical Review Letters, 1993, 71 (14), pp.2176-2179. ⟨10.1103/PhysRevLett.71.2176⟩. ⟨in2p3-00007600⟩
  • A. Figureau. L'evolution chimique et les origines de la vie. Origins of Life and Evolution of the Biosphere, 1993, 26, pp.217-219. ⟨in2p3-00022873⟩
  • P. Desgrolard, M. Giffon, L.L. Jenkovszky. Phenomenological implications of a perturbative pomeron beyond the dipole approximation. Yadernaya Fizika, 1993, 56, pp.226-237. ⟨in2p3-00009910⟩
  • A. Clouvas, A. Katsanos, B. Farizon-Mazuy, M. Farizon, M.J. Gaillard, et al.. Projectile dependence of ion induced electron emission from thin carbon foils. Physical Review B: Condensed Matter and Materials Physics (1998-2015), 1993, 48, pp.6832-6838. ⟨in2p3-00013036⟩
  • P. Desgrolard, M. Giffon, L.L. Jenkovszky. Phenomenological implications of a perturbative pomeron beyond the dipole approximation. Physics of Atomic Nuclei [Âdernaâ fizika / Yadernaya Fizika], 1993, 56, pp.1429-1436. ⟨in2p3-00009909⟩
  • C. Fayard, G.-H. Lamot, T. Mizutani, B. Saghai. Pi nn system with two-term potentials in the p_{33} and p_{11} \pi n channels. Physical Review C, 1993, 46, pp.118-132. ⟨in2p3-00000646⟩
  • A.J. Cole, M.E. Brandan, P. Desesquelles, A. Giorni, D. Heuer, et al.. Recoil effects in sequential emission and Coulomb dissociation. Physical Review C, 1993, 47, pp.1251-1256. ⟨10.1103/PhysRevC.47.1251⟩. ⟨in2p3-00013028⟩
  • O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, A. Aloisio, et al.. Results from the L3 experiment at LEP. Physics Reports, 1993, 236, pp.1-146. ⟨10.1016/0370-1573(93)90027-B⟩. ⟨in2p3-00023150⟩

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