Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • G. Klotz, P. Baumann, M. Bounajma, A. Huck, A. Knipper, et al.. Beta decay of ^{31.32}Na and ^{31}Mg: study of the N=20 shell closure. Physical Review C, 1993, 47, pp.2502-2516. ⟨in2p3-00013017⟩
  • C. Seonho, M.A. Duval, L. Elouadrhiri, V. Estenne, G. Bardin, et al.. Axial and pseudoscalar nucleon form factors from low energy pion electroproduction. Physical Review Letters, 1993, 71, pp.3927-3930. ⟨in2p3-00000615⟩
  • T. Mitzutani, C. Fayard, G.-H. Lamot, B. Saghai. Three-body approach to nn \rightarrow n \delta reaction. Physical Review C, 1993, 47, pp.56-68. ⟨in2p3-00000626⟩
  • P. Desesquelles, A.J. Cole, A. Giorni, D. Heuer, A. Lleres, et al.. Identification of a percolationlike critical region in the decay of excited calcium nuclei. Physical Review C, 1993, 48, pp.1828-1839. ⟨10.1103/PhysRevC.48.1828⟩. ⟨in2p3-00013030⟩
  • G. Marest, J. Parallada, G. Principi, C. Tosello. Cems study of ^{57}Fe implantation in nickel. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1993, 80/81, pp.309-312. ⟨in2p3-00013016⟩
  • O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, A. Aloisio, et al.. \chi_c production in hadronic Z decays. Physics Letters B, 1993, 317, pp.467-473. ⟨in2p3-00003546⟩
  • O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, A. Aloisio, et al.. Determination of the effective electroweak mixing angle from Z decays. Physics Letters B, 1993, 309, pp.451-462. ⟨10.1016/0370-2693(93)90961-G⟩. ⟨in2p3-00003542⟩
  • O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, A. Aloisio, et al.. Measurement of the average lifetime of b hadrons. Physics Letters B, 1993, 317, pp.474-484. ⟨10.1016/0370-2693(93)91027-K⟩. ⟨in2p3-00001219⟩
  • O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, A. Aloisio, et al.. Inclusive search for the charmless radiative decay of the B-quark (B\rightarrow S \gamma). Physics Letters B, 1993, 317, pp.637-646. ⟨10.1016/0370-2693(93)91384-Y⟩. ⟨in2p3-00001217⟩
  • F. Thimon, G. Marest, N. Moncoffre, S. Joshi, S.B. Ogale. Study of Fe:Al_2O_3 ion beam sputtered thin film with various iron contents. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1993, 80/81, pp.1241-1244. ⟨in2p3-00013042⟩

Powered by HAL logo