Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, A. Aloisio, et al.. Search for non-minimal Higgs bosons in Z^0 decays. Zeitschrift für Physik. C, Particles and Fields, 1993, 57, pp.355-381. ⟨10.1007/BF01474331⟩. ⟨in2p3-00001222⟩
  • J.A. Tuszynski, J.L. Rubin, J. Meyer, M. Kibler. Statistical mechanics of a q-deformed boson gas. Physics Letters A, 1993, 175, pp.173-177. ⟨in2p3-00000637⟩
  • B. Canut, S.M.M. Ramos, P. Thevenard, N. Moncoffre, A. Benyagoub, et al.. High energy heavy ion irradiation effects in alpha a \ell_2o_3. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1993, 80/81, pp.1114-1118. ⟨in2p3-00013029⟩
  • O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, A. Aloisio, et al.. Measurement of \Gamma_{b\overline{b}}/\Gamma_{had} from hadronic decays of the Z. Physics Letters B, 1993, 307, pp.237-246. ⟨10.1016/0370-2693(93)90214-3⟩. ⟨in2p3-00003569⟩
  • P. Abreu, W. Adam, T. Adye, E. Agasi, I. Azhinenko, et al.. A measurement of the mean lifetimes of charged and neutral B-hadrons. Physics Letters B, 1993, 312, pp.253-266. ⟨10.1016/0370-2693(93)90520-R⟩. ⟨in2p3-00001208⟩
  • J. Skalski, P.H. Heenen, P. Bonche, H. Flocard, J. Meyer. Octupole correlations in superdeformed mercury and lead nuclei - a generator coordinate method analysis. Nuclear Physics A, 1993, 551, pp.109-124. ⟨in2p3-00000645⟩
  • F. Gieres. Maurer-Cartan forms and equations for two-dimensional superdiffeomorphisms. Journal of Mathematical Physics, 1993, 34, pp.836-843. ⟨in2p3-00002478⟩
  • F. Gieres. On the holomorphic factorization for superconformal fields. Letters in Mathematical Physics, 1993, 28, pp.43-48. ⟨in2p3-00002476⟩
  • F. Gieres, S. Theisen. Superconformally covariant operators and super and W-algebras. Journal of Mathematical Physics, 1993, 34, pp.5964-5985. ⟨in2p3-00002477⟩
  • C. Tosello, F. Ferrari, R. Brand, W. Keune, G. Marest, et al.. Mixing effect of Fe/Ni multilayers of overall Fe_{65}Ni_{35} composition. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1993, 80/81, pp.417-420. ⟨in2p3-00013033⟩

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