Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • E. Vireton. Contribution a la modelisation de la pulverisation par faisceaux d'ions. Cosmology and Extra-Galactic Astrophysics [astro-ph.CO]. Université Claude Bernard - Lyon I, 1993. English. ⟨NNT : ⟩. ⟨in2p3-00007658⟩
  • P. Abreu, W. Adam, T. Adye, E. Agasi, R. Aleksan, et al.. Search for Z^0 decays to two leptons and a charged particle antiparticle pair. Nuclear Physics B, 1993, 403, pp.3-24. ⟨10.1016/0550-3213(93)90027-M⟩. ⟨in2p3-00001223⟩
  • O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, A. Aloisio, et al.. Determination of quark electroweak couplings from direct photon production in hadronic Z decays. Physics Letters B, 1993, 301, pp.136-144. ⟨10.1016/0370-2693(93)90735-Z⟩. ⟨in2p3-00003548⟩
  • O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, A. Aloisio, et al.. Search for a Z' at the Z resonance. Physics Letters B, 1993, 306, pp.187-196. ⟨10.1016/0370-2693(93)91156-H⟩. ⟨in2p3-00001221⟩
  • O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, A. Aloisio, et al.. Search for narrow vector resonances in the Z mass range. Physics Letters B, 1993, 313, pp.326-332. ⟨10.1016/0370-2693(93)91229-G⟩. ⟨in2p3-00001229⟩
  • D. Dauvergne. Processus de capture electronique par des ions lourds tres epluches canalises dans des cristaux minces a des energies superieures a 20 MeV/nucleon. Université Claude Bernard - Lyon I, 1993. English. ⟨NNT : ⟩. ⟨in2p3-00009659⟩
  • Didier Schmaus, S. Andriamonje, M. Chevallier, C. Cohen, N. Cue, et al.. Channeling of swift heavy ions. Radiation Effects and Defects in Solids, 1993, 126, pp.313-318. ⟨in2p3-00014386⟩
  • R.J.M. Covolan, P. Desgrolard, M. Giffon, L.L. Jenkovzky, E. Predazzi. Pomeron and odderon at high energies. Zeitschrift für Physik. C, Particles and Fields, 1993, 58, pp.109-117. ⟨in2p3-00009614⟩
  • G. Chanfray, P. Schuck. The rho meson in dense matter and its influence on dilepton production rates. Nuclear Physics A, 1993, 555, pp.329-354. ⟨10.1016/0375-9474(93)90325-R⟩. ⟨in2p3-00000627⟩
  • Z. Aouissat, G. Chanfray, P. Schuck. Influence of the particle-hole continuum on pion-pion correlations in dense nuclear matter. Modern Physics Letters A, 1993, 8, pp.1379-1385. ⟨10.1142/S0217732393001094⟩. ⟨in2p3-00000639⟩

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