Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • M. Rigault, J.D. Neill, N. Blagorodnova, A. Dugas, M. Feeney, et al.. Fully automated integral field spectrograph pipeline for the SEDMachine: pysedm. Astronomy & Astrophysics - A&A, 2019, 627, pp.A115. ⟨10.1051/0004-6361/201935344⟩. ⟨hal-02268432⟩
    • C. Aidala, Y. Akiba, M. Alfred, V. Andrieux, K. Aoki, et al.. Creation of quark–gluon plasma droplets with three distinct geometries. Nature Physics, 2019, 15 (3), pp.214-220. ⟨10.1038/s41567-018-0360-0⟩. ⟨hal-01802043⟩
    • Christoph Charles. Abelian 2+1D Loop Quantum Gravity Coupled to a Scalar Field. Gen.Rel.Grav., 2019, 51 (3), pp.48. ⟨10.1007/s10714-019-2532-3⟩. ⟨hal-01871705⟩
    • Junho Lee, Nicolas Chanon, Andrew Levin, Jing Li, Meng Lu, et al.. Polarization fraction measurement in same-sign WW scattering using deep learning. Physical Review D, 2019, 99 (3), pp.033004. ⟨10.1103/PhysRevD.99.033004⟩. ⟨hal-01975187⟩
    • R. Graziani, H.M. Courtois, G Lavaux, Y. Hoffman, R.B. Tully, et al.. The peculiar velocity field up to z \sim 0.05 by forward-modelling Cosmicflows-3 data. Monthly Notices of the Royal Astronomical Society, 2019, 488 (4), pp.5438-5451. ⟨10.1093/mnras/stz078⟩. ⟨hal-01990691⟩
    • Junho Lee, Nicolas Chanon, Andrew Levin, Jing Li, Meng Lu, et al.. Polarization fraction measurement in ZZ scattering using deep learning. Physical Review D, 2019, 100 (11), pp.116010. ⟨10.1103/PhysRevD.100.116010⟩. ⟨hal-02303018⟩
    • R. Brent Tully, Daniel Pomarede, Romain Graziani, Helene M. Courtois, Yehuda Hoffman, et al.. Cosmicflows-3: Cosmography of the Local Void. The Astrophysical Journal, 2019, 880 (1), pp.24. ⟨10.3847/1538-4357/ab2597⟩. ⟨hal-02153583⟩
    • L. Sarrasin, C. Gaillard, C. Panetier, Y. Pipon, N. Moncoffre, et al.. Effect of the Oxygen Potential on the Mo Migration and Speciation in UO_2 and UO_{2+x}. Inorg.Chem., 2019, 58 (8), pp.4761-4773. ⟨10.1021/acs.inorgchem.8b03076⟩. ⟨hal-02116819⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for top quark partners with charge 5/3 in the same-sign dilepton and single-lepton final states in proton-proton collisions at \sqrt{s}=13 TeV. JHEP, 2019, 03, pp.082. ⟨10.1007/JHEP03(2019)082⟩. ⟨hal-01902957⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for vector-like leptons in multilepton final states in proton-proton collisions at \sqrt{s} = 13 TeV. Phys.Rev.D, 2019, 100 (5), pp.052003. ⟨10.1103/PhysRevD.100.052003⟩. ⟨hal-02154215⟩

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