Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Measurements of differential Z boson production cross sections in proton-proton collisions at \sqrt{s} = 13 TeV. Journal of High Energy Physics, 2019, 12, pp.061. ⟨10.1007/JHEP12(2019)061⟩. ⟨hal-02317334⟩
  • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Production of the \rho(770){^{0}} meson in pp and Pb-Pb collisions at \sqrt{s_{\rm NN}} = 2.76 TeV. Physical Review C, 2019, 99 (6), pp.064901. ⟨10.1103/PhysRevC.99.064901⟩. ⟨hal-01801889⟩
  • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Transverse momentum spectra and nuclear modification factors of charged particles in Xe-Xe collisions at \sqrt{s_{\rm NN}} = 5.44 TeV. Physics Letters B, 2019, 788, pp.166-179. ⟨10.1016/j.physletb.2018.10.052⟩. ⟨hal-01801872⟩
  • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, et al.. Charged-particle pseudorapidity density at mid-rapidity in p-Pb collisions at \sqrt{s_{\rm{NN}}} = 8.16 TeV. European Physical Journal C: Particles and Fields, 2019, 79 (4), pp.307. ⟨10.1140/epjc/s10052-019-6801-9⟩. ⟨hal-01960390⟩
  • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, et al.. Multiplicity dependence of light-flavor hadron production in pp collisions at \sqrt{s} = 7 TeV. Physical Review C, 2019, 99 (2), pp.024906. ⟨10.1103/PhysRevC.99.024906⟩. ⟨hal-01862001⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for vector-like leptons in multilepton final states in proton-proton collisions at \sqrt{s} = 13 TeV. Physical Review D, 2019, 100 (5), pp.052003. ⟨10.1103/PhysRevD.100.052003⟩. ⟨hal-02154215⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Evidence for light-by-light scattering and searches for axion-like particles in ultraperipheral PbPb collisions at \sqrt{s_\mathrm{NN}} = 5.02 TeV. Physics Letters B, 2019, 797, pp.134826. ⟨10.1016/j.physletb.2019.134826⟩. ⟨hal-03171360⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Charged-particle angular correlations in XeXe collisions at \sqrt{s_{_\mathrm{NN}}}= 5.44 TeV. Physical Review C, 2019, 100 (4), pp.044902. ⟨10.1103/PhysRevC.100.044902⟩. ⟨hal-02008883⟩
  • W. Adam, T. Bergauer, E. Brondolin, M. Dragicevic, R. Frühwirth, et al.. The DAQ and control system for the CMS Phase-1 pixel detector upgrade. Journal of Instrumentation, 2019, 14 (10), pp.P10017. ⟨10.1088/1748-0221/14/10/P10017⟩. ⟨hal-02371628⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of electroweak WZ boson production and search for new physics in WZ + two jets events in pp collisions at \sqrt{s} = 13TeV. Phys.Lett.B, 2019, 795, pp.281-307. ⟨10.1016/j.physletb.2019.05.042⟩. ⟨hal-02000018⟩

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