Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • L. Deshayes, M. Charbonnier, M. Romand, Thomas Petit, N. Chevarier, et al.. Amorphous hydrogenated carbon films elaborated by plasma-assisted chemical vapour deposition : characterization of composition by nuclear methods. European Materials Research Society Conference, May 1993, Strasbourg, France. pp.264-268. ⟨in2p3-00007551⟩
  • A. Gizon, J. Genevey, J. Inchaouh, S. Andre, D. Barneoud, et al.. Investigation of the A = 131 decay chain : Low-energy levels in odd-A Ce and Pr isotopes. International Conference on Nuclear Spectroscopy and Nuclear Structure, Apr 1993, Dubna, Russia. pp.3. ⟨in2p3-00007231⟩
  • R. Béraud, R. Duffait, A. Emsallem, Y. Le Coz, M. Meyer, et al.. Development of the IGISOL technique for the study of exotic nuclei produced via (HI,xn) reactions. International Conference on Nuclear Spectroscopy and Nuclear Structure, Apr 1993, Dubna, Russia. ⟨in2p3-00007232⟩
  • Thomas Petit, A. Chevarier, N. Chevarier. Energetic ion scattering and flow discharge optical spectrometry characterization of amorphous hydrogenated carbon films elaborated by PACVD. International Ion Beam Surface Specific Analysis 3, Apr 1993, Namur, Belgium. ⟨in2p3-00009852⟩
  • J. Meyer, E. Chabanat, K. Bencheikh, J. Bartel, P. Quentin. Equilibrium shapes of rotating nuclei in a semiclassical approach. International Symposium on Nuclear and Particles Physics, Mar 1993, Glasgow, United Kingdom. ⟨in2p3-00008227⟩
  • N. Redon. EUROGAM : The detector and some first results. European Biennial Workshop on Nuclear Physics 2, Mar 1993, Megeve, France. ⟨in2p3-00008220⟩
  • M.G. Porquet, F. Hannachi, G. Bastin, V. Brindejonc, I. Deloncle, et al.. Two-proton high-K oblate structures in ^{194}Pb. European Biennial Workshop on Nuclear Physics 2, Mar 1993, Megeve, France. pp.407-417. ⟨in2p3-00013024⟩
  • G. Chanfray. Rho meson in dense matter and dilepton production rate. European Biennial Conference on Nuclear Physics 2, Mar 1993, Megeve, France. ⟨in2p3-00008291⟩
  • M. Kibler. Intensity formulas for multi-photon transitions in rare Earth systems. Winter Workshop on Spectroscopy and Structure of Rare Earth Systems, Mar 1993, Karpacz, Poland. ⟨in2p3-00008295⟩
  • M. Kibler, J. Sztucki. d and f electrons in a qp-quantized cubical field. Winter Workshop on Spectroscopy and Structure of Rare Earth Systems, Mar 1993, Karpacz, Poland. pp.857-866. ⟨in2p3-00008105⟩

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