Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- H. Rothard. Electron emission from swift hydrogen cluster impact. Conference On Polyatomic Ion Impact On Solids And Related Phenomena, Jun 1993, Saint-Malo, France. ⟨in2p3-00008296⟩
- M. Fallavier, R. Kirsch, J.-C. Poizat, J. Remillieux, H. Rothard, et al.. Upper limits on (d,d) fusion yields under cluster impact. Conference On Polyatomic Ion Impact On Solids And Related Phenomena, Jun 1993, Saint-Malo, France. ⟨in2p3-00008233⟩
- B. Farizon, M. Farizon, M.J. Gaillard, E. Gerlic, S. Ouaskit. Fragmentation of ionic hydrogen clusters. Conference On Polyatomic Ion Impact On Solids And Related Phenomena, Jun 1993, Saint-Malo, France. ⟨in2p3-00008229⟩
- C. Vieu, F. Azaiez, G. Baldsiefen, C. Bourgeois, R.M. Clark, et al.. First evidence for the magnetic character of transitions in the 'oblate bands' of
Pb. International Conference on the Future of Nuclear Spectroscopy, Jun 1993, Crete, Greece. pp.176-188. ⟨in2p3-00013049⟩ - Z. Aouissat, G. Chanfray, P. Schuck. Sigma-and-rho-mesons in dense matter. TAPS Workshop.2, May 1993, Guardamar, Spain. pp.234-257. ⟨in2p3-00002694⟩
- B. Roux, H. Jaffrezic, H. Chermette, A. Chevarier, N. Chevarier. Etude de la contamination en hydrogene du niobium destine a la construction de cavites resonantes supraconductrices - modelisation de la diffusion de l'hydrogene par dynamique moleculaire. Journee De La Societe Francaise De Chimie, May 1993, Paris, France. pp.PM. ⟨in2p3-00013243⟩
- P. Desgrolard, M. Giffon, A. Lengyel, E. Martynov. Comparative analysis of phenomenological models for pomeron at t=0(*). Workshop on Soft Physics, May 1993, Novy Svet, Ukraine. ⟨in2p3-00011237⟩
- M. Kibler. On some applications of quantum algebras. Conference au ``Colloque de l'Universite Lyon I - Universite de Lodz'', May 1993, Villeurbanne, France. ⟨in2p3-00008237⟩
- J. Meyer, P. Quentin, E. Chabanat, K. Bencheikh, J. Bartel. Equilibrium shapes of rotating nuclei in a semiclassical approach. International School-Seminar on Heavy Ion Physics 1, May 1993, Dubna, Russia. ⟨in2p3-00008228⟩
- R. Chehab, T. Baier, P. Jean, X. Artru, M. Chevallier, et al.. First results concerning a crystal radiator dedicated to positron production by photons from channeled multi-gev electrons. Biennial Particle Accelerator Conference.15, May 1993, Washington, United States. pp.3093-3095. ⟨in2p3-00001003⟩
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