Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • P. Antilogus, M. Chemarin, H. El Mamouni, J. Fay, D. Gelé, et al.. Updated parameters of the Z^0 resonance from combined preliminary data of the LEP experiments. International Europhysics Conference on High Energy Physics HEP 93, Jun 1993, Marseille, France. ⟨in2p3-00008211⟩
  • J. Fay. Neutrino counting from single photon events. International Europhysics Conference on High Energy Physics HEP 93, Jun 1993, Marseille, France. ⟨in2p3-00008257⟩
  • P. Vincent, G. Smadja. Determination of the semi-leptonic branching ratio of the b quark using single and dilepton events. International Europhysics Conference on High Energy Physics HEP 93, Jun 1993, Marseille, France. ⟨in2p3-00008213⟩
  • P. Antilogus, L. Mirabito, P. Vincent, G. Smadja. Measurement of the forward-backward asymmetry of e^+e^- \to Z^0 \to b\bar b using prompt muons. International Europhysics Conference on High Energy Physics HEP 93, Jun 1993, Marseille, France. ⟨in2p3-00008212⟩
  • M.C. Abreu, C. Baglin, A. Baldit, C. Barriere, M. Bedjidian, et al.. J/\psi \psi' and muon pair production in p-w and s-u collisions. Conference On Ultra-Relativistic Nucleus-Nucleus Collisions 10, Jun 1993, Borlaenge, Sweden. pp.77C-86C. ⟨in2p3-00002468⟩
  • M.C. Abreu, C. Baglin, A. Baldit, C. Barriere, M. Bedjidian, et al.. \psi' and J/\psi production in p-U and S-U collisions at 200 GeV/nucleon. Quark Matter '93, Conference On Ultra-Relativistic Nucleus-Nucleus Collisions. 10, Jun 1993, Borlaenge, Sweden. pp.371C-374C. ⟨in2p3-00003642⟩
  • H. Allali, B. Nsouli, J.-P. Thomas. A PDMS study of gamma-ray induced radiolysis of poly(4-vinylpyridrine). Particle Desorption Mass Analysis, Jun 1993, Kleinwalsertal, Austria. ⟨in2p3-00008251⟩
  • H. Allali, B. Nsouli, J.-P. Thomas. Depht of origin of secondary ions resulting from electronic sputtering of ultra-thin layers. Particle Desorption Mass Analysis, Jun 1993, Kleinwalsertal, Austria. ⟨in2p3-00008250⟩
  • P. Bonche, E. Chabanat, B.Q. Chen, J. Dobaczewski, H. Flocard, et al.. Microscopic approach to collective motion. International Conference On Perspectives In Nuclear Structure, Jun 1993, Copenhagen, Denmark. pp.185C-205C. ⟨in2p3-00007566⟩
  • R. Béraud. IGISOL with (HI,xn) reactions at SARA. Mid-Summer Workshop on Nuclear Physics, Jun 1993, Jyvaeskylae, Finland. ⟨in2p3-00008297⟩

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