Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • H. Allali, B. Nsouli, J.-P. Thomas. Phosphorous determination and secondary ion emission induced in silicon oxide by Ar ions of high (9 MeV) and low (30 keV) energy. International Conference on Atomic Collisions in Solids 15, Jul 1993, Kingston, Canada. ⟨in2p3-00008252⟩
  • D. Fabris, B. Chambon, B. Cheynis, D. Drain. The level density of hot compound nuclei with A_{CN} \tilde 40-106. International Nuclear Physics Conference, Jul 1993, Wiesbaden, Germany. ⟨in2p3-00008216⟩
  • M.E. Brandan, D. Benchekroun, B. Chambon, B. Cheynis, A. Demeyer, et al.. Momentum correlations in sequential decay and Coulomb dissociation. International Nuclear Physics Conference, Jul 1993, Wiesbaden, Germany. ⟨in2p3-00008217⟩
  • S. Andriamonje, Bertram Blank, R. del Moral, J.P. Dufour, L. Faux, et al.. Electronic capture and excitation of highly charged channeled ions. International Conference On X-Ray And Inner-Shell Processes'93 16, Jul 1993, Debrecen, Hungary. pp.116-123. ⟨in2p3-00014369⟩
  • Hakim Allali. Aspects de l'émission ionique secondaire induite dans des couches isolantes inorganiques par des ions d'Argon d'une dizaine de MeV. Physique Atomique [physics.atom-ph]. Université Claude Bernard - Lyon I, 1993. Français. ⟨NNT : ⟩. ⟨tel-00746656⟩
  • M. Kibler, C. Campigotto, Yu.F. Smirnov. Recursion relations for Clebsch-Gordan coefficients of U_q(SU_2) and U_q(SU_{1,1}). International Workshop on Symmetry Methods in Physics, Jul 1993, Dubna, Russia. pp.247-252. ⟨in2p3-00005215⟩
  • A. Figureau. Can biological homochirality results from a phase transition ?. International Conference of the Society for the Study of the Origin of Life 8, Jul 1993, Barcelone, Spain. ⟨in2p3-00012163⟩
  • D. Jouan, M.C. Abreu, C. Baglin, A. Baldit, C. Barriere, et al.. \psi' J/\psi and dimuon production in p-W ,p-U and S-U collisions at 200 GeV per nucleon. International Europhysics Conference on High Energy Physics HEP 93, Jul 1993, Marseille, France. ⟨in2p3-00007780⟩
  • S. Andriamonje, M. Chevallier, D. Dauvergne, R. Kirsch, J.-C. Poizat, et al.. Radiative electron capture by 60 MeV/A highly charged Kr ions channeled in a silicon single crystal - Amplitude and line shape analysis. International Conference PEAC 18, Jul 1993, Aarhus, Germany. ⟨in2p3-00008247⟩
  • M. Ericson. Quark condensate and the pion mass in the nuclear medium. International Conference On Particles And Nuclei 13, Jun 1993, Perugia, Italy. ⟨in2p3-00008293⟩

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