Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Z. Aouissat, G. Chanfray, P. Schuck. Sigma and rho mesons in dense matter. International Workshop on Dynamical Features of Nuclei and Finite Fermi Systems, Sep 1993, Sitges, Spain. pp.254-273. ⟨in2p3-00002695⟩
  • J.-F. Clergeau, D. Contardo, R. Haroutunian, L. Mirabito, G. Smadja. Simulation of MSGC signals and application to the front-end electronics for LHC experiments. International Conference on Position Sensitive Dectectors 4, Sep 1993, Manchester, United Kingdom. pp.109-114. ⟨in2p3-00014803⟩
  • X. Artru, M. Chevallier, B. Farizon, M. Farizon, M.J. Gaillard, et al.. Channeling and blocking effect in pair creation in a Ge crystal. International Symposium on Radiation of Relativistic Electrons in Periodical Structures, Sep 1993, Tomsk, Russia. ⟨in2p3-00008239⟩
  • X. Artru, M. Chevallier. Experimental results concerning a tungsten crystal radiator dedicated to positron production. International Symposium on Radiation of Relativistic Electrons in Periodical Structures, Sep 1993, Tomsk, Russia. ⟨in2p3-00008240⟩
  • C. Bacci, P. Belli, R. Bernabei, C. Dai, W. Di Nicolantonio, et al.. Status report on dark matter search with low activity scintillators. TAUP 93 Theoretical and Phenomenological Aspects of Underground Physics, Sep 1993, L'Aquilla (Gran Sasso), Italy. pp.159-161. ⟨in2p3-00005253⟩
  • J-M. Marty, A. Benyagoub, G. Marest, N. Moncoffre. Moessbauer study of sappohire irradiated with high energy heavy ions. International Conference on Radiation Effects in Insulators - Radiation Effects In Insulators 7, Aug 1993, Nagoya, Japan. ⟨in2p3-00008231⟩
  • P. Antilogus, M. Chemarin, H. El Mamouni, J. Fay, D. Gelé, et al.. Updated parameters of the Z^0 resonance from combined preliminary dat of the LEP experiments. International Symposium on Lepton-Photon Interactions at High Energies, Aug 1993, Cornell, United Kingdom. ⟨in2p3-00008214⟩
  • G. Marest, N. Moncoffre, F. Thimon, M. Brunel, C. Esnouf. Synthesis of Fe:Al_2O_3 thin films by ion beam sputtering - interface effect. Applications of the Moessbauer Effect, Aug 1993, Vancouver, Canada. pp.1303-1309. ⟨in2p3-00013006⟩
  • M. Kibler. Miscellaneous physical applications of quantum algebras. International Symposium on Mathematical Physics, Jul 1993, Clausthal, Germany. pp.55-67. ⟨in2p3-00003191⟩
  • M.E. Brandan, B. Chambon, B. Cheynis, D. Drain, C. Pastor. Effects of the observables introduced by multidetector systems. International Nuclear Physics Conference, Jul 1993, Wiesbaden, Germany. ⟨in2p3-00008215⟩

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