Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • A. Figureau. Biomolecular homochirality and weak interactions amplification. Conference on Chemical Evolution and the Origin of Life 2, Oct 1993, Trieste, Italy. ⟨in2p3-00012164⟩
  • X. Artru. Proposals for measuring tranversity distributions in deep inelastic electron scattering and a model for E-704 asymmetries. International Workshop on High Energy Spin Physics 5, Sep 1993, Protvino, Russia. ⟨in2p3-00008236⟩
  • F. Rogemond, H. Chermette. Structure electronique et vibrationnelle de CuCl_2 par la methode de la fonctionnelle de la densite : possibilite d'une nouvelle interpretation des proprietes spectroscopique. Congres des Chimistes Theoricens d'Expression Latine 21, Sep 1993, Grenoble, France. ⟨in2p3-00013528⟩
  • G. Gardet, F. Rogemond, H. Chermette. Etude theorique de la stabilite relative des isomeres Li_6. Congres des Chimistes Theoricens d'Expression Latine 21, Sep 1993, Grenoble, France. ⟨in2p3-00013527⟩
  • B. Roussiere, J. Genevey, A. Gizon, F. Ibrahim, P. Kilcher, et al.. M3 transitions in odd and odd-odd nuclei. International Symposium Capture Gamma-Ray Spectroscopy and Related Topics 8, Sep 1993, Fribourg, Switzerland. pp.231-235. ⟨in2p3-00013220⟩
  • F. Ibrahim, D. Barneoud, R. Béraud, G. Cata-Danil, J. Blachot, et al.. Structure of low-spin states in ^{184}Au. International Symposium on Capture Gamma-Ray Spectroscopy and Related Topics 8, Sep 1993, Fribourg, Switzerland. pp.386-388. ⟨in2p3-00013075⟩
  • F.M. Michel-Calendini, K. Bellafrouh, H. Chermette. EPR optical and properties of Co^{2+} in MgO from LSD molecular orbital calculations. International Conference on the Applications of the Density Functional Theory in Chemistry and Physics 5, Sep 1993, Como, Italy. ⟨in2p3-00013529⟩
  • F. Bohr, H. Chermette, M.F. Ruiz-Lopez. A density functional study of pseudotetrahedral metal-nitrosyl complexes. International Conference on the Applications of the Density Functional Theory in Chemistry and Physics 5, Sep 1993, Como, Italy. pp.1039-1049. ⟨in2p3-00012960⟩
  • J. Meyer. Forces effectives aux frontières de la stabilité. École thématique. Ecole Joliot Curie "Les noyaux en 1993 : une nouvelle façon d'exister", Maubuisson, (France), du 13-18 septembre 1993 : 12ème session, 1993. ⟨cel-00648738⟩
  • N. Moncoffre, J. Jagielski. Redistribution of nitrogen implanted into iron: role of carbon and radiation defects. Surface Modification of Metals by Ion Beams, Sep 1993, Kanazawa, Japan. pp.30-36. ⟨in2p3-00013008⟩

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