Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • P. Abreu, W. Adam, T. Adye, E. Agasi, R. Aleksan, et al.. Invariant mass dependence of particle correlations in hadronic final states from the decay of the Z^0. Zeitschrift für Physik. C, Particles and Fields, 1994, 63, pp.17-28. ⟨10.1007/BF01577540⟩. ⟨in2p3-00002691⟩
  • G. Chanfray, D. Davesne. Pion dispersion relation in hot pion matter. Zeitschrift für Physik. A, Atoms and Nuclei, 1994, 349, pp.65-76. ⟨in2p3-00000573⟩
  • M. Acciarri, A. Adam, O. Adriani, M. Aguilar-Benitez, S. Ahlen, et al.. Measurement of cross sections and leptonic forward-backward asymmetries at the Z pole and determination of electroweak parameters. Zeitschrift für Physik. C, Particles and Fields, 1994, 62, pp.551-573. ⟨10.1007/BF01574160⟩. ⟨in2p3-00003536⟩
  • X. Artru, V.N. Baier, R. Chehab, A. Jejcic. Positron source using channeling in a tungstene crystal. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1994, 344, pp.443-454. ⟨in2p3-00001001⟩
  • M. Chemarin, P. Depasse, J. Fay, M. Felcini, L. Fredj, et al.. Test beam results for an upgraded forward tagger of the l3 experiment at lep ii. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1994, 349, pp.345-355. ⟨in2p3-00007580⟩
  • J.A. Bakken, L. Barone, A. Bay, J.J. Blaising, B. Borgia, et al.. Results on the calibration of the L3 BGO calorimeter with cosmic rays. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1994, 343, pp.456-462. ⟨in2p3-00023151⟩
  • N. Millard-Pinard, H. Jaffrezic, G. Marest, N. Moncoffre, J. Tousset, et al.. Nitrogen implantation in iron : influence of the beam current density and of the chamber residual pressure. Radiation Effects and Defects in Solids, 1994, 128, pp.295-305. ⟨in2p3-00007569⟩
  • H. Allali, B. Cabaud, G. Fuchs, A. Hoareau, B. Nsouli, et al.. Secondary ion emission from ultra-thin oxide layers bombarded by energetic (mev) heavy ions - depth of origin and layer homogeneity. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1994, 84, pp.303-309. ⟨in2p3-00007584⟩
  • Y. Le Coz, N. Redon, A. Astier, R. Béraud, R. Duffait, et al.. Two proton high-spin excitations and dipole bands in ^{192}Hg. Zeitschrift für Physik. A, Atoms and Nuclei, 1994, 348, pp.87-93. ⟨in2p3-00007572⟩
  • A. Billebaud, D. Dauvergne, M. Fallavier, R. Kirsch, J.-C. Poizat, et al.. Emission electronique secondaire sous impact d'agregats rapides. Journees Scientifiques du GDR ``Agregats'', Nov 1993, Orsay, France. ⟨in2p3-00008255⟩

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