Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • P. Abreu, W. Adam, T. Adye, E. Agasi, R. Aleksan, et al.. Study of hard scattering processes in multihadron production from \gamma \gamma collisions at Lep. Zeitschrift für Physik. C, Particles and Fields, 1994, 62, pp.357-365. ⟨10.1007/BF01555895⟩. ⟨in2p3-00007585⟩
  • J.-F. Clergeau, D. Contardo, G. Smadja. The Micro-strip gas chamber behaviour in a magnetic field. 1994. ⟨in2p3-00014779⟩
  • K. Hagel, M. Gonin, R. Wada, J.B. Natowitz, Fayrouz. Haddad, et al.. Violent collisions and multifragment final states in the ^{40}Ca + ^{40}Ca reaction at 35 MeV/nucleon. Physical Review C, 1994, 50, pp.2017-2034. ⟨10.1103/PhysRevC.50.2017⟩. ⟨in2p3-00000535⟩
  • M.J. Joyce, J.F. Sharpey-Schafer, M.A. Riley, D.M. Cullen, F. Azaiez, et al.. The N=7 unfavoured superdeformed band in ^{193}Hg : Coriolis splitting and neutron shell structure at extreme deformation. Physics Letters B, 1994, 340, pp.150-154. ⟨in2p3-00007575⟩
  • R. Barbier, J. Meyer, M. Kibler. An u_{qp}(u_2) model for rotational bands of nuclei. Journal of Physics G: Nuclear and Particle Physics, 1994, 20, pp.L13-L19. ⟨in2p3-00000521⟩
  • M. Fallavier, M. Benmansour, B. Hjorvarsson, J.-P. Thomas, M. Abon, et al.. Hydrogen on Pt_{0.5}Ni_{0.5}(110) alloying effects upon adsorption. Surface Science : A Journal Devoted to the Physics and Chemistry of Interfaces, 1994, 311, pp.24-32. ⟨in2p3-00007563⟩
  • J. Benlliure, A. Chbihi, P. Ecomard, A. Le Fevre, Nathalie Marie, et al.. First results from Indra. Nouvelles de Ganil, 1994, 49, pp.3-12. ⟨in2p3-00009606⟩
  • R. Béraud, A. Emsallem, A. Astier, R. Bouvier, R. Duffait, et al.. Development of a new Sara/Igisol technique for the study of short-lived products from heavy-ion-induced fusion-evaporation reactions. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1994, 346, pp.196-204. ⟨10.1016/0168-9002(94)90704-8⟩. ⟨in2p3-00012961⟩
  • S. Ouaskit, B. Farizon, M. Farizon, M.J. Gaillard, A. Chevarier, et al.. Fragmentation of high-energy ionic hydrogen clusters by single collision with helium. International journal of mass spectrometry and ion processes, 1994, 139, pp.141-146. ⟨10.1016/0168-1176(94)90026-4⟩. ⟨in2p3-00007557⟩
  • G. Chanfray, D. Davesne. Pion dispersion relation in hot pion matter. Zeitschrift für Physik. A, Atoms and Nuclei, 1994, 349, pp.65-76. ⟨in2p3-00000573⟩

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