Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Thomas Carreau, Francesca Gulminelli, Jérôme Margueron. Bayesian analysis of the crust-core transition with a compressible liquid-drop model. The European physical journal. A, Hadrons and Nuclei, 2019, 55 (10), pp.188. ⟨10.1140/epja/i2019-12884-1⟩. ⟨hal-02058549⟩
    • Ke-Pan Xie, Giacomo Cacciapaglia, Thomas Flacke. Exotic decays of top partners with charge 5/3: bounds and opportunities. Journal of High Energy Physics, 2019, 10, pp.134. ⟨10.1007/JHEP10(2019)134⟩. ⟨hal-02272670⟩
    • Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. Production of muons from heavy-flavour hadron decays in pp collisions at \sqrt{s} = 5.02 TeV. Journal of High Energy Physics, 2019, 09, pp.008. ⟨10.1007/JHEP09(2019)008⟩. ⟨hal-02148293⟩
    • Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. Measurement of prompt D^{0}, D^{+}, D^{*+}, and {\mathrm{D}}_{\mathrm{S}}^{+} production in p–Pb collisions at \sqrt{{\mathrm{s}}_{\mathrm{NN}}} = 5.02 TeV. Journal of High Energy Physics, 2019, 12, pp.092. ⟨10.1007/JHEP12(2019)092⟩. ⟨hal-02166465⟩
    • Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. Study of the \Lambda-\Lambda interaction with femtoscopy correlations in pp and p-Pb collisions at the LHC. Physics Letters B, 2019, 797, pp.134822. ⟨10.1016/j.physletb.2019.134822⟩. ⟨hal-02148247⟩
    • K. Wrzosek-Lipska, K. Rezynkina, N. Bree, M. Zielińska, L.P. Gaffney, et al.. Electromagnetic properties of low-lying states in neutron-deficient Hg isotopes: Coulomb excitation of ^{182}Hg, ^{184}Hg, ^{186}Hg and ^{188}Hg. The European physical journal. A, Hadrons and Nuclei, 2019, 55 (8), pp.130. ⟨10.1140/epja/i2019-12815-2⟩. ⟨hal-02277788⟩
    • A. Goldkuhle, C. Fransen, A. Blazhev, M. Beckers, B. Birkenbach, et al.. Lifetime measurements in ^{52,54}Ti to study shell evolution toward N=32. Physical Review C, 2019, 100 (5), pp.054317. ⟨10.1103/PhysRevC.100.054317⟩. ⟨hal-02381948⟩
    • Simone Ferraro, Michael J. Wilson, Muntazir Abidi, David Alonso, Behzad Ansarinejad, et al.. Astro2020 Science White Paper: Inflation and Dark Energy from Spectroscopy at z > 2. Bull.Am.Astron.Soc., 2019, 51 (3), pp.72. ⟨hal-02116530⟩
    • Victor Mukhamedovich Abazov, Braden Keim Abbott, Bannanje Sripath Acharya, Mark Raymond Adams, Todd Adams, et al.. Properties of Z_c^{\pm}(3900) Produced in p \bar p Collision. Phys.Rev.D, 2019, 100, pp.012005. ⟨10.1103/PhysRevD.100.012005⟩. ⟨hal-02160632⟩
    • F. Acernese, M. Agathos, L. Aiello, A. Allocca, A. Amato, et al.. Increasing the Astrophysical Reach of the Advanced Virgo Detector via the Application of Squeezed Vacuum States of Light. Phys.Rev.Lett., 2019, 123 (23), pp.231108. ⟨10.1103/PhysRevLett.123.231108⟩. ⟨hal-02416888⟩

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