Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J. Delorme, M. Ericson. S-wave pion-nucleus interaction and weak coupling constants. Physical Review C, 1994, 49, pp.R1763-R1767. ⟨in2p3-00000602⟩
  • M. Ericson. Possible way out of the (p;n) puzzle. Physical Review C, 1994, 49, pp.R2293-R2296. ⟨10.1103/PhysRevC.49.R2293⟩. ⟨in2p3-00000574⟩
  • J. Jagielski, N. Moncoffre, G. Marest, L. Thome, A.J. Barcz, et al.. Radiation-induced segregation of nitrogen implanted into iron. Journal of Applied Physics, 1994, 75, pp.153-160. ⟨in2p3-00013007⟩
  • P. Desgrolard, M. Giffon, A. Lengyel, E. Martynov. Comparative analysis implications of a phenomenological models for pomeron at T=O. Il Nuovo Cimento, 1994, 107, pp.637-647. ⟨in2p3-00011704⟩
  • M.G. Porquet, F. Hannachi, G. Bastin, V. Brindejonc, I. Deloncle, et al.. Two-proton high-K oblate structures in ^{194}Pb. Journal of Physics G: Nuclear and Particle Physics, 1994, 20, pp.765-773. ⟨in2p3-00007571⟩
  • R.G. Henry, T. Lauritsen, T.L. Khoo, I. Ahmad, M.P. Carpenter, et al.. Spectrum of gamma rays connecting superdeformed and normal states in ^{192}Hg. Physical Review Letters, 1994, 73, pp.777-781. ⟨in2p3-00007582⟩
  • J. Duprat, C. Vieu, F. Azaiez, G. Baldsiefen, C. Bourgeois, et al.. First evidence of the magnetic character of dipole transitions in the 'oblate bands' of ^{199}Pb. Zeitschrift für Physik. A, Atoms and Nuclei, 1994, 347, pp.289-290. ⟨in2p3-00013050⟩
  • P. Desgrolard, M. Giffon, E. Predazzi. High quality description of elastic high energy data and prediction on new phenomena. Zeitschrift für Physik. C, Particles and Fields, 1994, 63, pp.241-252. ⟨in2p3-00000524⟩
  • M. Napolitano. Developpement d'un systeme de pilotage en temps reel selon une approche orientee objets d'un bati de depot sous vide utilisant la technologie DIBS - Mise en oeuvre de cet outil et application a la realisation de couches minces d'oxydes dans le cadre du projet VIRGO. Cosmology and Extra-Galactic Astrophysics [astro-ph.CO]. Université Claude Bernard - Lyon I, 1994. English. ⟨NNT : ⟩. ⟨in2p3-00011577⟩
  • Vincent Paillard, P. Melinon, J.P. Perez, V. Dupuis, A. Perez, et al.. Mechanical properties of nanostructured diamond-like carbon films synthesized by low energy cluster beam deposition. Nanostructured Materials, 1994, 4, pp.759-767. ⟨in2p3-00007565⟩

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