Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J. Duprat, B.J.P. Gall, M.G. Porquet, F. Hannachi, F. Azaiez, et al.. First observation of a superdeformed nucleus produced in an \alpha xn reaction channel. Zeitschrift für Physik. A, Atoms and Nuclei, 1994, 349, pp.5-6. ⟨in2p3-00002460⟩
  • J. Duprat, F. Azaiez, C. Bourgeois, J.F. Sharpey-Schafer, M.G. Porquet, et al.. M1 transitions between superdeformed states in ^{195}Tl : the fingerprint of the i_{13/2} proton intruder orbital. Physics Letters B, 1994, 341, pp.6-11. ⟨in2p3-00007581⟩
  • F. Ibrahim, P. Kilcher, B. Roussiere, J. Sauvage, J. Genevey, et al.. Spin and parity of isomeric and ground states of the doubly-odd nucleus ^{184}Au. Zeitschrift für Physik. A, Atoms and Nuclei, 1994, 350, pp.9-10. ⟨10.1007/BF01285045⟩. ⟨in2p3-00007583⟩
  • K. Baudin, A. Brunelle, M. Chabot, S. Della-Negra, J. Depauw, et al.. Energy loss by mev carbon clusters and fullerene ions in solids. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1994, 94, pp.341-344. ⟨in2p3-00003520⟩
  • P.F. Box, K.A. Griffioen, P. Decowski, T. Bootsma, E. Gierlik, et al.. Inclusive systematics for ^{28}Si + ^{28}Si reactions between 20 and 35 MeV per nucleon. Physical Review C, 1994, 50, pp.934-951. ⟨10.1103/PhysRevC.50.934⟩. ⟨in2p3-00007558⟩
  • D. Heuer, A. Chabane, M.E. Brandan, M. Charvet, A.J. Cole, et al.. Explosive multifragmentation in the ^{32}s + ^{27}al reaction at 37.5 mev/nucleon. Physical Review C, 1994, 50, pp.1943-1951. ⟨10.1103/PhysRevC.50.1943⟩. ⟨in2p3-00007556⟩
  • F. Thimon, G. Marest, N. Moncoffre. Moessbauer study of Fe-Al-O layers obtained by ion-beam deposition and ion implantation. Thin Solid Films, 1994, 237, pp.208-212. ⟨in2p3-00007567⟩
  • B. Farizon, M. Farizon, M.J. Gaillard, S. Ouaskit. Physics with high-energy cluster beams. Computational Materials Science, 1994, 2, pp.571-577. ⟨in2p3-00014382⟩
  • A. Lleres, A.J. Cole, P. Desesquelles, A. Giorni, D. Heuer, et al.. Deexcitation of primary projectile-like fragments in the reaction ^{40}Ca + ^{nat}Cu at 35 MeV/nucleon : comparison with sequential binary decay and percolation models. Physical Review C, 1994, 50, pp.1973-1981. ⟨10.1103/PhysRevC.50.1973⟩. ⟨in2p3-00007553⟩
  • J.-M. Richard, S. Fleck. Limits on the domain of coupling constants for binding n-body systems with no bound subsystems. Physical Review Letters, 1994, 73, pp.1464-1467. ⟨10.1103/PhysRevLett.73.1464⟩. ⟨in2p3-00000525⟩

Powered by HAL logo