Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • H. Allali, B. Nsouli, J.-P. Thomas, W. Szymczack, K. Wittmaack. Comparison of secondary ion emission induced in silicon oxide by MeV and keV ion bombardment. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1994, 90, pp.501-504. ⟨in2p3-00008261⟩
  • F. Angelini, R. Bellzzini, A. Brez, M.M. Massai, R. Raffo, et al.. Behaviour of microstrip gas chamber in strong magnetic field. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1994, 343, pp.441-446. ⟨in2p3-00014784⟩
  • M. Novello, E. Elbaz. Soft-big-bang model induced by non-minimal coupling. Il Nuovo Cimento B, 1994, 109, pp.741-746. ⟨in2p3-00000604⟩
  • M. Kibler. Multiphoton laser spectroscopy of transition ions in crystals : recent progress in the use of symmetry considerations. Laser Physics, 1994, 4, pp.38-40. ⟨in2p3-00000526⟩
  • G. Chanfray, M. Ericson, M. Kirchbach. Pion decay constant and the gell-mann-oakes-renner relation in nuclei. Modern Physics Letters A, 1994, 9, pp.279-287. ⟨10.1142/S0217732394000290⟩. ⟨in2p3-00000572⟩
  • C O. Bacri, B. Borderie, J L. Charvet, A. Chbihi, D. Cussol, et al.. Vaporization of the Ar + Ni system studied with the 4 \pi multidetector INDRA. International Workshop on Multiparticle Correlations and Nuclear Reactions CORINNE II, 1994, Nantes, France. pp.338-353. ⟨in2p3-00005191⟩
  • P. Abreu, W. Adam, T. Adye, E. Agasi, I. Azhinenko, et al.. Search for the standard model Higgs boson in Z^0 decays. Nuclear Physics B, 1994, 421, pp.3-40. ⟨10.1016/0550-3213(94)90222-4⟩. ⟨in2p3-00007586⟩
  • R. Menegazzo, P. Kleinheinz, R. Collatz, H. Gueven, J. Styczen, et al.. The N=83 nucleus ^{149}Dy from Gamow-Teller decay of its 11/2^- and 1/2^+ ^{149}Ho parents. Zeitschrift für Physik. A, Atoms and Nuclei, 1994, 349, pp.13-24. ⟨in2p3-00013005⟩
  • S. Ouaskit, B. Farizon, M. Farizon, M.J. Gaillard, E. Gerlic. Dissociation cross sections of ionic hydrogen clusters by collisions with helium at 60 kev/amu. Physical Review A : Atomic, molecular, and optical physics [1990-2015], 1994, 49, pp.1484-1486. ⟨in2p3-00002459⟩
  • B.J.P. Gall, M.G. Porquet, F. Hannachi, A. Korichi, I. Ahmad, et al.. New results on the superdeformed band in ^{192}Hg. Zeitschrift für Physik. A, Atoms and Nuclei, 1994, 347, pp.223-224. ⟨in2p3-00007568⟩

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