Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. Yvert, B. Caron, A. Dominjon, F. Marion, L. Massonnet, et al.. Status of the VIRGO experiment. Meeting On Advanced Detectors 6, May 1994, La Biodola,Isola D'Elba, Italy. pp.258-262. ⟨in2p3-00002455⟩
  • P. Vincent. Mesure des rapports d'embranchement semi-leptoniques et de la contribution baryonique dans les desintegrations du quark b. Physique des Hautes Energies - Expérience [hep-ex]. Université Claude Bernard - Lyon I, 1994. Français. ⟨NNT : ⟩. ⟨in2p3-00002740⟩
  • M.C. Abreu, C. Baglin, A. Baldit, C. Barriere, M. Bedjidian, et al.. J/\psi and \psi' production in the NA38 experiment. Rencontres De Moriond 29, Mar 1994, Meribel, France. pp.1-6. ⟨in2p3-00007593⟩
  • M.C. Abreu, B. Alessandro, A. Baldit, C. Barriere, M. Bedjidian, et al.. Study of the isospin symmetry breaking in the light quark sea of the nucleon from the Drell-Yan process. Rencontres De Moriond, Mar 1994, Meribel Les Allues, France. pp.229-234. ⟨in2p3-00004340⟩
  • M. Ericson. The S-wave \pi-nucleus interaction and the (p,n) puzzle. Spin-Isospin Responses and Weak Porcesses in Hadrons and Nuclei, Mar 1994, Osaka, Japan. pp.147C-152C. ⟨in2p3-00007573⟩
  • Y. Déclais. Neutrino oscillation at reactors. International Workshop on Neutrino Telescopes 6, Feb 1994, Venezia, Italy. pp.604. ⟨in2p3-00007712⟩
  • D. Benchekroun, B. Chambon, B. Cheynis, A. Demeyer, D. Drain, et al.. Particle correlations in the search for multifragmentation. International Winter Meeting on Nuclear Physics.32, Jan 1994, Bormio, Italy. pp.151-160. ⟨in2p3-00001980⟩
  • P. Belli, C. Bacci, R. Bernabei, C J. Dai, W. Di Nicolantonio, et al.. New limits on axial coupled WIMPs with scintillators. Rencontre de Moriond : '94 Moriond Workshop on Particle Astrophysics, Atomic Physics and Gravitation 29, Jan 1994, Villars Sur Ollon, Switzerland. ⟨in2p3-00012105⟩
  • B. Berthier, A. Demeyer, C. Donnet, D. Guinet, P. Lautesse, et al.. Recent results from Nautilus and Indra. International Workshop on Gross Properties of Nuclei and Nuclear Exitations 22, Jan 1994, Hirschegg, Australia. ⟨in2p3-00008314⟩
  • N. Millard-Pinard, H. Jaffrezic, G. Marest, N. Moncoffre, J. Tousset, et al.. Nitrogen implantation in iron : influence of the beam current density and of the chamber residual pressure. Radiation Effects and Defects in Solids, 1994, 128, pp.295-305. ⟨in2p3-00007569⟩

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