Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • P. Quentin, D. Samsoen, K. Bencheikh, E. Chabanat, J. Meyer, et al.. Spin and isospin dependence of the nuclear liquid drop parametrization. International Conference on Nuclear Shapes and Nuclear Structure at Low Excitation Energies, Jun 1994, Antibes, France. pp.283-294. ⟨in2p3-00004120⟩
  • A. Astier, R. Béraud, A. Emsallem, Y. Le Coz. Alpha-decay of ^{180}Tl studied with the SARA/IGISOL facility. Nuclear Shapes and Nuclear Structure at Low Excitation Energies Abstracts of Contributed Papers, Jun 1994, Antibes, France. ⟨in2p3-00008316⟩
  • J. Duprat, M. Aiche, A. Astier, F. Azaiez, G. Bastin, et al.. Magnetic properties of superformed nuclei around ^{192}Hg and their neutron and proton single particle configurations. Nuclear Shapes and Nuclear Structure at Low Excitation Energies Abstracts of Contributed Papers, Jun 1994, Antibes, France. pp.30. ⟨in2p3-00013068⟩
  • M. Giffon, M. Bertini, L. Jenkovszky. Small x analysis of the proton structure function. Rencontres de Blois 6, Jun 1994, Blois, France. pp.447-450. ⟨in2p3-00010901⟩
  • F. Ibrahim, D. Barneoud, R. Béraud, G. Cata-Danil, J. Blachot, et al.. Is a shape coexistence present in ^{184}Au ?. Nuclear Shapes and Nuclear Structure at Low Excitation Energies Abstracts of Contributed Papers, Jun 1994, Antibes, France. pp.42. ⟨in2p3-00013052⟩
  • A. Astier, R. Béraud, R. Duffait, Y. Le Coz, M. Meyer, et al.. Two proton high-spin excitations and oblate dipole bands in ^{192}Hg. Nuclear Shapes and Nuclear Structure at Low Excitation Energies Abstracts of Contributed Papers, Jun 1994, Antibes, France. pp.7. ⟨in2p3-00013078⟩
  • P. Schuurmans, I. Berkes, M. de Jésus. Alpha anisotropy measurements on on-line separated At and Rn isotopes. Nuclear Shapes and Nuclear Structure at Low Excitation Energies Abstracts of Contributed Papers, Jun 1994, Antibes, France. ⟨in2p3-00012166⟩
  • R. Henry, R. Béraud, Y. Le Coz, M. Meyer, N. Redon. Decay from superdeformed to normal states in ^{192}Hg spectrum of connecting \gamma rays. International Conference On Nucleus-Nucleus Collisions 5, May 1994, Taormina, Italy. ⟨in2p3-00008315⟩
  • D. Heuer, A. Chabane, M.E. Brandan, M. Charvet, A.J. Cole, et al.. Blast expansion in ^{32}S + ^{27}Al at 37.5 MeV/nucleon. International Conference On Nucleus-Nucleus Collisions 5, May 1994, Taormina, Italy. pp.537-542. ⟨in2p3-00007535⟩
  • C. Bacci, P. Belli, R. Bernabei, C J. Dai, W. Di Nicolantonio, et al.. Particle dark matter search with low activity scintillators: status report. Vulcano Workshop 1994 on Frontier Objects in Astrophysics and Particle Physics, May 1994, Vulcano, Italy. pp.6. ⟨in2p3-00007672⟩

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