Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of the top quark mass in the all-jets final state at \sqrt{s} = 13 TeV and combination with the lepton+jets channel. Eur.Phys.J.C, 2019, 79 (4), pp.313. ⟨10.1140/epjc/s10052-019-6788-2⟩. ⟨hal-01982957⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for heavy neutrinos and third-generation leptoquarks in hadronic states of two \tau leptons and two jets in proton-proton collisions at \sqrt{s} = 13 TeV. JHEP, 2019, 03, pp.170. ⟨10.1007/JHEP03(2019)170⟩. ⟨hal-01937639⟩
    • X. Artru. Radiation by an electron in an electromagnetic plane wave: The quasiclassical formula and other domains of applications. Physical Review Accelerators and Beams, 2019, 22 (5), pp.050705. ⟨10.1103/PhysRevAccelBeams.22.050705⟩. ⟨hal-02166563⟩
    • A. Bianchi, S. Delsanto, P. Dupieux, A. Ferretti, M. Gagliardi, et al.. Characterization of tetrafluoropropene-based gas mixtures for the Resistive Plate Chambers of the ALICE muon spectrometer. Journal of Instrumentation, 2019, 14 (11), pp.P11014. ⟨10.1088/1748-0221/14/11/P11014⟩. ⟨hal-02192536⟩
    • Guillaume Victor, Yves Pipon, Nathalie Moncoffre, Nicolas Bererd, Claude Esnouf, et al.. In situ TEM observations of ion irradiation damage in boron carbide. Journal of the European Ceramic Society, 2019, 39, pp.726-734. ⟨10.1016/j.jeurceramsoc.2018.11.011⟩. ⟨hal-01976926⟩
    • Giacomo Cacciapaglia, Thomas Flacke, Myeonghun Park, Mengchao Zhang. Exotic decays of top partners: mind the search gap. Physics Letters B, 2019, 798, pp.135015. ⟨10.1016/j.physletb.2019.135015⟩. ⟨hal-02302833⟩
    • Rebecca Meissner, Linda Feketeová, Anita Ribar, Katharina Fink, Paulo Limão-Vieira, et al.. Electron Ionization of Imidazole and Its Derivative 2-Nitroimidazole. Journal of The American Society for Mass Spectrometry, 2019, 30 (12), pp.2678-2691. ⟨10.1007/s13361-019-02337-w⟩. ⟨hal-02447932⟩
    • Peng Wang, Quan Guo, Noam I. Libeskind, Elmo Tempel, Chengliang Wei, et al.. The shape alignment of satellite galaxies in Local Group-like pairs from the SDSS. Monthly Notices of the Royal Astronomical Society, 2019, 484 (3), pp.4325-4336. ⟨10.1093/mnras/stz285⟩. ⟨hal-02080607⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of B^0_\mathrm{s} meson production in pp and PbPb collisions at \sqrt{s_\mathrm{NN}} = 5.02 TeV. Phys.Lett.B, 2019, 796, pp.168-190. ⟨10.1016/j.physletb.2019.07.014⟩. ⟨hal-01902956⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, et al.. Multiplicity dependence of (anti-)deuteron production in pp collisions at \sqrt{s} = 7 TeV. Physics Letters B, 2019, 794, pp.50-63. ⟨10.1016/j.physletb.2019.05.028⟩. ⟨hal-02066929⟩

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