Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. Kibler, R.M. Asherova, Yu.F. Smirnov. Some aspects of q- and qp-boson calculus. Symposium on Symmetries in Science 8, Aug 1994, Bregenz, Austria. pp.465. ⟨in2p3-00002409⟩
  • M. Acciarri, A. Adam, O. Adriani, M. Aguilar-Benitez, S. Ahlen, et al.. Measurement of exclusive branching fractions of hadronic one-prong tau decays. Meeting of the Division of Particles and Fields of the American Physical Society - DPF '94 8, Aug 1994, Albuquerque, United States. pp.93-102. ⟨in2p3-00001187⟩
  • Y. Le Coz, A. Astier, R. Béraud, R. Duffait, M. Meyer, et al.. Two proton high spin excitations and dipole bands in ^{192}Hg. International Symposium on New Structure Phenomena in the Vicinity of Closed Shells, Aug 1994, Stockholm, Sweden. pp.234-235. ⟨in2p3-00013023⟩
  • F. Azaiez, J. Duprat, J.F. Sharpey-Schafer, M. Aiche, G. Bastin, et al.. M1 transitions between superdeformed states in ^{194,195}Tl: the fingerprint of the i_{13/2} proton intruder orbital. International Symposium on New Structure Phenomena in the Vicinity of Closed Shells, Aug 1994, Stockholm, Sweden. pp.35-38. ⟨in2p3-00013000⟩
  • J.-P. Burq, M. Chemarin, P. Depasse, H. El Mamouni, J.-P. Ernenwein, et al.. Search for the standard model Higgs boson in Z decays. International Conference on High Energy Physics 27, Jul 1994, Glasgow, United Kingdom. ⟨in2p3-00008310⟩
  • J.-P. Burq, M. Chemarin, P. Depasse, H. El Mamouni, J.-P. Ernenwein, et al.. Searches for non-minimal Higgs bosons in Z decays. International Conference on High Energy Physics 27, Jul 1994, Glasgow, United Kingdom. ⟨in2p3-00008311⟩
  • J.-P. Burq, M. Chemarin, P. Depasse, H. El Mamouni, J.-P. Ernenwein, et al.. Combined preliminary data on Z parameters from the LEP experiments and constraints on the standard model. International Conference on High Energy Physics 27, Jul 1994, Glasgow, United Kingdom. ⟨in2p3-00008309⟩
  • R. Barbier, M. Kibler. A system of interest in spectroscopy - the qp-rotor system. International Workshop on Finite Dimensional Integrable Systems, Jul 1994, Dubna, Russia. pp.23-32. ⟨in2p3-00003205⟩
  • R. Béraud. Alpha- and beta-decay properties of very n-deficient Tl isotopes. Conference on Selected Topics in Nuclear Structure 4, Jul 1994, Dubna, Russia. ⟨in2p3-00008306⟩
  • P. Bonche, E. Chabanat, B. Q Chen, J. Dobaczewski, H. Flocard, et al.. Microscopic approach to collective motion. Nuclear Physics A, 1994, 574 (1-2), pp.185c-205c. ⟨10.1016/0375-9474(94)90045-0⟩. ⟨cea-02928290⟩

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