Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J.-C. David, C. Fayard, G.-H. Lamot, B. Saghai. Electromagnetic production of K\Sigma on the proton. European Conference on Few-Body Problems in Physics 15, Jun 1995, Peniscola, Spain. ⟨in2p3-00008165⟩
  • Ch. Charles, J.-C. David, C. Fayard, M. Guidal, G.-H. Lamot, et al.. Electromagnetic associated strangeness production and hadrons form factors. European Conference on Few-Body Problems in Physics 15, Jun 1995, Peniscola, Spain. ⟨in2p3-00008166⟩
  • L. Pinard, P. Ganau, J.-M. Mackowski, C. Michel, M. Napolitano, et al.. Low loss DIBS mirrors 1064 nm for the VIRGO interferometer. Optical Interference Coatings Conference'95, Jun 1995, Tucson, United States. pp.200-203. ⟨in2p3-00003242⟩
  • A. Korichi, F. Hannachi, I. Deloncle, W. Korten, I. Ahmad, et al.. Observation and lifetime of the first excited superdeformed band in ^{192}Hg. International Conference on Exotic Nuclei and Atomic Masses, Jun 1995, Arles, France. pp.575-576. ⟨in2p3-00013003⟩
  • M. Bertini, M. Giffon, E. Predazzi. Polarized structure functions from deep inelastic scattering. Rencontres de Blois 7, Jun 1995, Blois, France. ⟨in2p3-00008167⟩
  • M. Bertini, M. Giffon, E. Predazzi. D0 we really need more than one Pomeron. Rencontres de Blois 7, Jun 1995, Blois, France. ⟨in2p3-00009847⟩
  • P. Martin, A. Chevarier, N. Chevarier, G. Barbier. Use of HIRBS to study distortion of implanted lanthanides distribution in apatite during ion bombardment. International Conference on Ion Beam Analysis 12 IBA 12, Jun 1995, Tempe, United States. ⟨in2p3-00008187⟩
  • H. Rothard, A. Billebaud. Fluence dependent electron emission as a measure of surface modification induced by swift heavy ions. International Conference on Swift Heavy Ions In Matter SHIM'95, May 1995, Caen, France. ⟨in2p3-00008170⟩
  • S. Andriamonje, M. Chevallier, C. Cohen, N. Cue, D. Dauvergne, et al.. Influence of intrashell excitation (N=2) on the population of mestastable states of h- and he-like krypton ions in channeling conditions. International Conference On Swift Heavy Ions In Matter 3, May 1995, Caen, France. pp.1-5. ⟨in2p3-00007532⟩
  • A.N. Willson, J. Timar, J.F. Sharpey-Schafer, B. Crowell, M.P. Carpenter, et al.. First evidence of collective vibrations of superdeformed nuclei. Divisional Conference on Low-Energy Nuclear Dynamics 15, Apr 1995, St. Petersburg, Russia. pp.545-552. ⟨in2p3-00014575⟩

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