Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • A. de Bellefon, L. Berge, I. Berkes, C. Bobin, D. Broszkiewicz, et al.. Dark matter search with thermal detectors. International Europhysics Conference on High Energy Physics, Jul 1995, Brussels, Belgium. ⟨in2p3-00005250⟩
  • D. Bertini. Beauty baryon production properties and lifetimes. International Europhysics Conference HEP'95, Jul 1995, Brussels, Belgium. ⟨in2p3-00008195⟩
  • P. Antilogus. Measurement of the forward backward asymmetries of b\bar b and c\bar c. International Europhysics Conference HEP'95, Jul 1995, Brussels, Belgium. ⟨in2p3-00008193⟩
  • J.-P. Burq, M. Chemarin, P. Depasse, H. El Mamouni, J.-P. Ernenwein, et al.. Seach for neutral Higgs boson production through the process \to Z*H^0. International Europhysics Conference HEP'95, Jul 1995, Brussels, Belgium. ⟨in2p3-00018886⟩
  • F. Malek. A di-muon spectrometer to study charmonium production. ELFE Summer School on Confinement Physics 1, Jul 1995, Cambridge, United Kingdom. ⟨in2p3-00008308⟩
  • H. Rothard, A. Billebaud, M. Chevallier. Transport of swift heavy ion induced electrons in solids. International Conference on Atomic Collisions in Solids 16 Icacs 16, Jul 1995, Linz, Austria. ⟨in2p3-00008171⟩
  • A. Billebaud, M. Fallavier, R. Kirsch, J.-C. Poizat, J. Remillieux, et al.. Experimental study of emission yields and statistics of secondary electrons from thin carbon foils bombarded by atomic and molecular projectiles. International Conference on Atomic Collisions in Solids Icacs 16, Jul 1995, Linz, Austria. ⟨in2p3-00008172⟩
  • F. Garrido, A. Benyagoub, A. Chamberod, J.C. Dran, A. Dunlop, et al.. Giant deformation of solids irradiated with swift heavy ions: behavior of amorphous/crystalline multilayers. International Conference on Atomic Collisions in Solids 16 Icacs, Jul 1995, Linz, Austria. pp.430-439. ⟨in2p3-00012952⟩
  • B. Roussiere, P. Kilcher, A. Wojtasiewicz, J. Obert, J.C. Putaux, et al.. M3 transitions in odd and odd-odd nuclei. International Conference on Exotic Nuclei and Atomic Masses ENAM 95, Jun 1995, Arles, France. pp.593-594. ⟨in2p3-00001226⟩
  • F. Ibrahim, D. Barneoud, R. Béraud, J. Blachot, C. Bourgeois, et al.. The ^{184}Au puzzle. International Conference on Exotic Nuclei and Atomic Masses 1 ENAM 95, Jun 1995, Arles, France. pp.493-498. ⟨in2p3-00000838⟩

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