Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- R. Barbier. Algèbre quantique U
(u
) et application à la dynamique collective de rotation dans les noyaux. Université Claude Bernard - Lyon I, 1995. English. ⟨NNT : ⟩. ⟨in2p3-00002439⟩ - A. De Bellefon, L. Bergé, I. Berkes, C. Bobin, D. Broszkiewicz, et al.. First results of the EDELWEISS experiment. International Workshop on Theoretical and Phenomenological Aspects of Underground Physics (TAUP 95) 4, Sep 1995, Toledo, Spain. pp.77-79. ⟨in2p3-00005081⟩
- M. Acciarri, A. Adam, O. Adriani, M. Aguilar-Benitez, S. Ahlen, et al.. Measurement of
production in two and three-jet events from hadronic Z decays at Lep. International Symposium on Multiparticle Dynamics Stara 25, Sep 1995, Lesna, Slovakia. pp.126-136. ⟨in2p3-00003504⟩ - B. Nsouli, P. Rumeau, H. Allali, B. Chabert, O. Debré, et al.. Plasma desorption time-of-flight mass spectrometric elucidation of the mechanisms of adhesion enhancement between plasma-treated peek-carbon composite and an epoxyamine adhesive. Journees Francaises de Spectrometrie de Masse 12, Sep 1995, Bordeaux, France. pp.1566-1571. ⟨in2p3-00012955⟩
- B. Nsouli, H. Allali, B. Chabert, O. Debré, A. Oladipo, et al.. Contributiom de la technique TOF-PMDS a l'etude des mecanismes d'adhesion entre un composite PEEK/carbone et un adhesif epoxy-amine. Journees Francaises de Spectrometrie de Masse 12, Sep 1995, Bordeaux, France. ⟨in2p3-00009849⟩
- O. Drapier. Le plasma de quarks et de gluons : signatures expérimentales. École thématique. Ecole Joliot Curie "Noyaux en collisions", Maubuisson, (France), du 11-16 septembre 1995 : 14ème session, 1995. ⟨cel-00650126⟩
- A. Faussemagne, G. Marest, A. Benyagoub, N. Moncoffre. Moessbauer study of boron and nitrogen dual implantation in a 100Cr6 steel. International Conference on Applications of the Moessbauer Effect, Sep 1995, Rimini, Italy. ⟨in2p3-00008192⟩
- A. Faussemagne, P. Delichère, N. Moncoffre, A. Benyagoub, G. Marest. Study of BN formation by dual implantation of boron and nitrogen in a 100Cr6 bearing steel. International Cofnerence on Surface Modifications of Metals by Ions Beams, Sep 1995, San Sebastian, Spain. pp.70-73. ⟨in2p3-00008190⟩
- P. Martin, A. Chevarier, N. Chevarier. Migration of lanthanides in apatite layers during alpha irradiation. Migration'95 Conference, Sep 1995, Saint-Malo, France. ⟨in2p3-00008188⟩
- O. Drapier. Les collisions d'ions lourds ultrarelativistes. Congres General de Physique de la S.F.P., Sep 1995, Marseille, France. ⟨in2p3-00008180⟩
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