Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • P. Abreu, W. Adam, T. Adye, E. Agasi, R. Aleksan, et al.. Mean lifetime of the b^{0}_{s} meson. Zeitschrift für Physik. C, Particles and Fields, 1996, 71, pp.11-30. ⟨10.1007/s002880050144⟩. ⟨in2p3-00001177⟩
  • X. Artru, J. Collins. Measuring transverse spin correlations by 4-particle correlations in e^+e^- \rightarrow 2 jets. Zeitschrift für Physik. C, Particles and Fields, 1996, 69, pp.277-286. ⟨10.1007/s002880050028⟩. ⟨in2p3-00002438⟩
  • P. Abreu, W. Adam, T. Adye, E. Agasi, I. Azhinenko, et al.. Measurement of inclusive k*^0(892) \phi(1020) and k*_2^0(1430) production in hadronic Z decays. Zeitschrift für Physik. C, Particles and Fields, 1996, 73, pp.61-72. ⟨10.1007/s002880050296⟩. ⟨in2p3-00002452⟩
  • Z. Aouissat, G. Chanfray, P. Schuck, J. Wambach. A non-perturbative treatment of the pion in the linear sigma-model. Nuclear Physics A, 1996, 603, pp.458-470. ⟨10.1016/0375-9474(96)80011-F⟩. ⟨in2p3-00000453⟩
  • M. Acciarri, A. Adam, O. Adriani, M. Aguilar-Benitez, S. Ahlen, et al.. Measurement of hadron and lepton-pair production at 130 GeV \sqrt {s} 140 GeV at LEP. Physics Letters B, 1996, 370, pp.195-210. ⟨10.1016/0370-2693(96)00039-1⟩. ⟨in2p3-00001178⟩
  • M. Kaci, M.G. Porquet, F. Hannachi, M. Aiche, G. Bastin, et al.. Dipole bands in the oblate-shaped ^{195}Pb. Zeitschrift für Physik. A, Atoms and Nuclei, 1996, 354, pp.267-275. ⟨in2p3-00009591⟩
  • L. Ducroux, A. Astier, R. Duffait, Y. Le Coz, M. Meyer, et al.. Dipole bands and multi-quasiparticle excitations in ^{193}Pb. Zeitschrift für Physik. A, Atoms and Nuclei, 1996, 356, pp.241-249. ⟨in2p3-00007561⟩
  • L. Beaulieu, Y. Larochelle, L. Gingras, G.C. Ball, D.R. Bowman, et al.. Direct measurement of dissipation in the ^{35}Cl + ^{12}C reaction at 43 mev/nucleon. Physical Review Letters, 1996, 77, pp.462-465. ⟨in2p3-00012932⟩
  • V. Chazal. Etude de l'environnement neutron au laboratoire souterrain de Modane. Cosmology and Extra-Galactic Astrophysics [astro-ph.CO]. Université Claude Bernard - Lyon I, 1996. English. ⟨NNT : ⟩. ⟨in2p3-00003691⟩
  • G. Chanfray, R. Rapp, J. Wambach. Medium modifications of the Rho meson at CERN super proton Synchrotron energies (200 GeV/nucleon). Physical Review Letters, 1996, 76, pp.368-371. ⟨in2p3-00008129⟩

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