Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • P. Abreu, W. Adam, T. Adye, E. Agasi, I. Ajinenko, et al.. Measurement of the partial decay width R_{b}^{0}= \Gamma_{b\overline{b}}/\Gamma_{had} of the Z with the DELPHI detector at Lep. Zeitschrift für Physik. C, Particles and Fields, 1996, 70, pp.531-547. ⟨10.1007/s002880050131⟩. ⟨in2p3-00003516⟩
  • P. Abreu, W. Adam, T. Adye, E. Agasi, I. Azhinenko, et al.. Search for promptly produced heavy quarkonium states in hadronic Z decays. Zeitschrift für Physik. C, Particles and Fields, 1996, 69, pp.575-583. ⟨10.1007/s002880050061⟩. ⟨in2p3-00002451⟩
  • P. Abreu, W. Adam, T. Adye, E. Agasi, I. Azhinenko, et al.. Search for the lightest chargino at \sqrt{s} = 130 and 136 GeV. Physics Letters B, 1996, 382, pp.323-336. ⟨10.1016/0370-2693(96)00769-1⟩. ⟨hal-05066713⟩
  • P. Abreu, W. Adam, T. Adye, E. Agasi, I. Ajinenko, et al.. Search for exclusive decays of the \Lambda_{b} baryon and measurement of its mass. Physics Letters B, 1996, 374, pp.351-361. ⟨10.1016/0370-2693(96)00306-1⟩. ⟨in2p3-00014365⟩
  • B. Nsouli, P. Dole, H. Allali, J. Chauchard, J.-P. Thomas. Thermooxidation-induced surface modifications of the ethylene-methyl acrylate copolymer as investigated by time-of-flight particle-induced desorption mass spectrometry Part I : Individual homopolymers. Rapid Communications in Mass Spectrometry, 1996, 10, pp.157-161. ⟨in2p3-00008262⟩
  • R. Somatri-Bouamrane. Caracterisation des elements carbone azote oxygene et metal refractaire dans des depots binaires et ternaires a base de silicium par methodes d'analyse utilisant les faisceaux d'ions. Nuclear Experiment [nucl-ex]. Université Claude Bernard - Lyon I, 1996. English. ⟨NNT : ⟩. ⟨in2p3-00007660⟩
  • A. Figureau. Les origines de la vie. Origins of Life and Evolution of the Biosphere, 1996, 26, pp.195-196. ⟨in2p3-00022874⟩
  • M. Acciarri, A. Adam, O. Adriani, M. Aguilar-Benitez, S. Ahlen, et al.. Study of the structure of hadronic events and determination of \alpha_{s} at \sqrt{s} = 130 GeV and 136 GeV. Physics Letters B, 1996, 371, pp.137-148. ⟨10.1016/0370-2693(96)00096-2⟩. ⟨in2p3-00023158⟩
  • C. Vincent-Donnet, M. Stern, E. Gerlic, M.T. Magda, B. Chambon, et al.. Fragmentation and massive transfer in (semi)peripheral collisions via the 35a mev ^{22}Ne + ^{93}Nb system. Journal of Physics G: Nuclear and Particle Physics, 1996, 22, pp.397-413. ⟨10.1088/0954-3899/22/3/013⟩. ⟨in2p3-00012951⟩
  • S. Perriès, A. Astier, L. Ducroux, R. Duffait, Y. Le Coz, et al.. Possible candidates for discrete gamma rays linking superdeformed and yrast states in an odd nucleus: ^{193}Pb. Zeitschrift für Physik. A, Atoms and Nuclei, 1996, 356, pp.1-2. ⟨in2p3-00012974⟩

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