Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • P. Abreu, W. Adam, T. Adye, E. Agasi, I. Ajinenko, et al.. Determination of the average lifetime of b-baryons. Zeitschrift für Physik. C, Particles and Fields, 1996, 71, pp.199-210. ⟨10.1007/s002880050164⟩. ⟨in2p3-00001175⟩
  • N.V. de Castro Faria, G. Jalbert, L.F.S. Coehlho, B. Farizon-Mazuy, M. Farizon, et al.. Interaction between fast h^+_n clusters and carbon foils. Brazilian Journal of Physics, 1996, 26, pp.577-589. ⟨in2p3-00007521⟩
  • A.J. Cole, A. Chabane, M. Charvet, P. Desesquelles, A. Giorni, et al.. Charge partition probabilities in the ^{32}S + ^{27}Al reaction at 37.5 MeV/nucleon analysed using the boltzmann distribution. Zeitschrift für Physik. A, Atoms and Nuclei, 1996, 356, pp.171-181. ⟨10.1007/s002180050164⟩. ⟨in2p3-00007529⟩
  • M. Bertini, M. Giffon, L. Jenkovszky, F. Paccanoni. Real part of the scattering amplitude and model analysis. Il Nuovo Cimento A, 1996, 109, pp.257-270. ⟨in2p3-00000429⟩
  • G. Chanfray, M. Ericson, J. Wambach. The quark condensate at finite temperature. Physics Letters B, 1996, 388, pp.673-678. ⟨in2p3-00000466⟩
  • B. Nsouli, M. Draye, H. Allali, M. Lemaire, J.-P. Thomas. Energy deposition and fragments production resulting from gamma-ray or ion beam irradiation of an ion echange resin. International journal of mass spectrometry and ion processes, 1996, 154, pp.179-191. ⟨10.1016/0168-1176(96)04381-9⟩. ⟨in2p3-00008259⟩
  • P. Willsau, M. Neffgen, Y. Le Coz, H. Hubel, W. Korten, et al.. Lifetimes of a dipole cascade in ^{192}Hg. Zeitschrift für Physik. A, Atoms and Nuclei, 1996, 355, pp.129-134. ⟨in2p3-00012969⟩
  • M. Kibler, L.G. Mardoyan, G.S. Pogosyan. On a Generalized Oscillator System: Interbasis Expansions. International Journal of Quantum Chemistry, 1996, 63, pp.133-148. <a target="_blank" href="https://dx.doi.org/10.1002/(SICI)1097-461X(1997)63:13.0.CO;2-D">⟨10.1002/(SICI)1097-461X(1997)63:13.0.CO;2-D⟩. ⟨in2p3-00115764⟩
  • M.C. Abreu, C. Baglin, A. Baldisseri, A. Baldit, M. Bedjidian, et al.. Muon pair and vector meson cross-sections in p-W and S-U collisions at 200 GeV/nucleon. Physics Letters B, 1996, 368, pp.230-238. ⟨in2p3-00005080⟩
  • R. Barbier, M. Kibler. Application of a two-parameter quantum algebra to rotational spectroscopy of nuclei. Reports on Mathematical Physics, 1996, 38, pp.221-226. ⟨in2p3-00008115⟩

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