Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J. Bartel, K. Bencheikh, E. Chabanat, J. Meyer, I.N. Mikhailov, et al.. Extended thomas-fermi description of rotating nuclei. Acta Physica Polonica B, 1996, 27, pp.133-137. ⟨in2p3-00014359⟩
  • P. Abreu, W. Adam, T. Adye, E. Agasi, I. Ajinenko, et al.. Search for high mass \gamma\gamma resonances in e^+e^- \rightarrow l^{+}l^{-}\gamma\gamma\nu\overline{\nu}\gamma\gamma and q\overline{q}\gamma\gamma at LEP I. Zeitschrift für Physik. C, Particles and Fields, 1996, 72, pp.179-190. ⟨10.1007/s002880050236⟩. ⟨in2p3-00003510⟩
  • P. Abreu, W. Adam, T. Adye, E. Agasi, I. Ajinenko, et al.. Performance of the DELPHI detector. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1996, 378, pp.57-100. ⟨10.1016/0168-9002(96)00463-9⟩. ⟨in2p3-00002449⟩
  • R. Somatri, Jean-François Chailan, A. Chevarier, N. Chevarier, G. Ferro, et al.. Alpha backscattering used in stoichiometry determination of thin sic coatings on si(100) wafers. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1996, 113, pp.284-287. ⟨in2p3-00012931⟩
  • A. Benyagoub, A. Chamberod, J.C. Dran, A. Dunlop, F. Garrido, et al.. Creep of a crystalline metallic layer induced by high-energy heavy-ion irradiation. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1996, 107, pp.189-192. ⟨in2p3-00007531⟩
  • A. de Bellefon, I. Berkes, C. Bobin, D. Broszkiewicz, B. Chambon, et al.. Dark matter search with a low temperature sapphire bolometer. Astroparticle Physics, 1996, 6, pp.35-43. ⟨in2p3-00005135⟩
  • P. Abreu, W. Adam, T. Adye, I. Ajinenko, G D. Alekseev, et al.. An upper limit for Br(Z^0 \rightarrow ggg) from Symmetric 3-jet Z^0 Hadronic Decays. Physics Letters B, 1996, 389, pp.405-415. ⟨10.1016/S0370-2693(96)01450-5⟩. ⟨in2p3-00001172⟩
  • A. Szczurek, M. Ericson, H. Holtmann, J. Speth. Testing the meson cloud in the nucleon in Drell-Yan processes. Nuclear Physics A, 1996, 596, pp.397-414. ⟨10.1016/0375-9474(95)00401-7⟩. ⟨in2p3-00129424⟩
  • F. Zach. Mesure du temps de vie du meson B^0_s et etude de ses oscillations temporelles par le detecteur Delphi au LEP. High Energy Physics - Experiment [hep-ex]. Université Claude Bernard - Lyon I, 1996. English. ⟨NNT : ⟩. ⟨in2p3-00003690⟩
  • H. El Mamouni. Memoire de synthese des travaux scientifiques. High Energy Physics - Experiment [hep-ex]. Université Claude Bernard - Lyon I, 1996. ⟨in2p3-00004193⟩

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