Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • P. Abreu, W. Adam, T. Adye, E. Agasi, I. Ajinenko, et al.. Search for neutralinos scalar leptons and scalar quarks in e^+e^- interactions at \sqrt{s} = 130 GeV and 136 GeV. Physics Letters B, 1996, 387, pp.651-666. ⟨10.1016/0370-2693(96)01197-5⟩. ⟨in2p3-00003511⟩
  • P. Abreu, W. Adam, T. Adye, E. Agasi, I. Azhinenko, et al.. Study of radiative leptonic events with hard photons and search for excited charged leptons at \sqrt s = 130-136 GeV. Physics Letters B, 1996, 380, pp.480-490. ⟨10.1016/0370-2693(96)00672-7⟩. ⟨in2p3-00003515⟩
  • M.C. Abreu, B. Alessandro, C. Alexa, J. Astruc, C. Baglin, et al.. Evidence of strong J/\psi and \psi suppression in high energy Pb-Pb interactions. International Symposium on Multiparticle Dynamics 26, 1996, Faro, Portugal. ⟨in2p3-00022990⟩
  • M.C. Abreu, C. Baglin, A. Baldisseri, A. Baldit, M. Bedjidian, et al.. Muon pair and vector meson cross-sections in p-W and S-U collisions at 200 GeV/nucleon. Physics Letters B, 1996, 368, pp.230-238. ⟨in2p3-00005080⟩
  • P. Abreu, W. Adam, T. Adye, E. Agasi, I. Ajinenko, et al.. Determination of the average lifetime of b-baryons. Zeitschrift für Physik. C, Particles and Fields, 1996, 71, pp.199-210. ⟨10.1007/s002880050164⟩. ⟨in2p3-00001175⟩
  • E. Auffray, T. Beckers, J. Bourotte, R. Chipaux, V. Commichau, et al.. Performance of a cerium fluoride crystal matrix measured in high-energy particle beams. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1996, 378, pp.171-178. ⟨10.1016/0168-9002(96)00223-9⟩. ⟨in2p3-00002536⟩
  • M. Bertini, M. Giffon, L. Jenkovszky, F. Paccanoni. Real part of the scattering amplitude and model analysis. Il Nuovo Cimento A, 1996, 109, pp.257-270. ⟨in2p3-00000429⟩
  • M. Kibler, L.G. Mardoyan, G.S. Pogosyan. On a Generalized Oscillator System: Interbasis Expansions. International Journal of Quantum Chemistry, 1996, 63, pp.133-148. <a target="_blank" href="https://dx.doi.org/10.1002/(SICI)1097-461X(1997)63:13.0.CO;2-D">⟨10.1002/(SICI)1097-461X(1997)63:13.0.CO;2-D⟩. ⟨in2p3-00115764⟩
  • P. Willsau, M. Neffgen, Y. Le Coz, H. Hubel, W. Korten, et al.. Lifetimes of a dipole cascade in ^{192}Hg. Zeitschrift für Physik. A, Atoms and Nuclei, 1996, 355, pp.129-134. ⟨in2p3-00012969⟩
  • B. Nsouli, M. Draye, H. Allali, M. Lemaire, J.-P. Thomas. Energy deposition and fragments production resulting from gamma-ray or ion beam irradiation of an ion echange resin. International journal of mass spectrometry and ion processes, 1996, 154, pp.179-191. ⟨10.1016/0168-1176(96)04381-9⟩. ⟨in2p3-00008259⟩

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