Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • B.P. Abbott, R. Abbott, T.D. Abbott, S. Abraham, F. Acernese, et al.. Search for Eccentric Binary Black Hole Mergers with Advanced LIGO and Advanced Virgo during their First and Second Observing Runs. Astrophys.J., 2019, 883 (2), pp.149. ⟨10.3847/1538-4357/ab3c2d⟩. ⟨hal-02999728⟩
    • N. Baillot d'Etivaux, Sebastien Guillot, Jérôme Margueron, Natalie Webb, Márcio Catelan, et al.. New constraints on the nuclear equation of state from the thermal emission of neutron stars in quiescent low-mass X-ray binaries. The Astrophysical Journal, 2019, 887 (1), pp.48. ⟨10.3847/1538-4357/ab4f6c⟩. ⟨hal-02144167⟩
    • W. Adam, T. Bergauer, E. Brondolin, M. Dragicevic, R. Frühwirth, et al.. The DAQ and control system for the CMS Phase-1 pixel detector upgrade. JINST, 2019, 14 (10), pp.P10017. ⟨10.1088/1748-0221/14/10/P10017⟩. ⟨hal-02371628⟩
    • S. Sels, T. Day Goodacre, B.A. Marsh, A. Pastore, W. Ryssens, et al.. Shape staggering of midshell mercury isotopes from in-source laser spectroscopy compared with density-functional-theory and Monte Carlo shell-model calculations. Physical Review C, 2019, 99 (4), pp.044306. ⟨10.1103/PhysRevC.99.044306⟩. ⟨hal-02097388⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Analysis of the apparent nuclear modification in peripheral Pb–Pb collisions at 5.02 TeV. Physics Letters B, 2019, 793, pp.420-432. ⟨10.1016/j.physletb.2019.04.047⟩. ⟨hal-01801903⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, et al.. Multiplicity dependence of light-flavor hadron production in pp collisions at \sqrt{s} = 7 TeV. Physical Review C, 2019, 99 (2), pp.024906. ⟨10.1103/PhysRevC.99.024906⟩. ⟨hal-01862001⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Transverse momentum spectra and nuclear modification factors of charged particles in Xe-Xe collisions at \sqrt{s_{\rm NN}} = 5.44 TeV. Physics Letters B, 2019, 788, pp.166-179. ⟨10.1016/j.physletb.2018.10.052⟩. ⟨hal-01801872⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, et al.. Charged-particle pseudorapidity density at mid-rapidity in p-Pb collisions at \sqrt{s_{\rm{NN}}} = 8.16 TeV. European Physical Journal C: Particles and Fields, 2019, 79 (4), pp.307. ⟨10.1140/epjc/s10052-019-6801-9⟩. ⟨hal-01960390⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Production of the \rho(770){^{0}} meson in pp and Pb-Pb collisions at \sqrt{s_{\rm NN}} = 2.76 TeV. Physical Review C, 2019, 99 (6), pp.064901. ⟨10.1103/PhysRevC.99.064901⟩. ⟨hal-01801889⟩
    • C. Amsler, M. Antonello, A. Belov, G. Bonomi, R.S. Brusa, et al.. A ∼100 \mum-resolution position-sensitive detector for slow positronium. Nucl.Instrum.Meth.B, 2019, 457, pp.44-48. ⟨10.1016/j.nimb.2019.07.015⟩. ⟨hal-02290802⟩

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