Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • A. Adare, S. Afanasiev, C. Aidala, N.N. Ajitanand, Y. Akiba, et al.. Measurement of two-particle correlations with respect to second- and third-order event planes in Au+Au collisions at \sqrt{s_{_{NN}}}=200 GeV. Physical Review C, 2019, 99 (5), pp.054903. ⟨10.1103/PhysRevC.99.054903⟩. ⟨hal-01802103⟩
  • C. Amsler, M. Antonello, A. Belov, G. Bonomi, R.S. Brusa, et al.. A ∼100 \mum-resolution position-sensitive detector for slow positronium. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2019, 457, pp.44-48. ⟨10.1016/j.nimb.2019.07.015⟩. ⟨hal-02290802⟩
  • R. Brent Tully, Daniel Pomarede, Romain Graziani, Helene M. Courtois, Yehuda Hoffman, et al.. Cosmicflows-3: Cosmography of the Local Void. The Astrophysical Journal, 2019, 880 (1), pp.24. ⟨10.3847/1538-4357/ab2597⟩. ⟨hal-02153583⟩
  • Junho Lee, Nicolas Chanon, Andrew Levin, Jing Li, Meng Lu, et al.. Polarization fraction measurement in ZZ scattering using deep learning. Physical Review D, 2019, 100 (11), pp.116010. ⟨10.1103/PhysRevD.100.116010⟩. ⟨hal-02303018⟩
  • Junho Lee, Nicolas Chanon, Andrew Levin, Jing Li, Meng Lu, et al.. Polarization fraction measurement in same-sign WW scattering using deep learning. Physical Review D, 2019, 99 (3), pp.033004. ⟨10.1103/PhysRevD.99.033004⟩. ⟨hal-01975187⟩
  • L. Sarrasin, C. Gaillard, C. Panetier, Y. Pipon, N. Moncoffre, et al.. Effect of the Oxygen Potential on the Mo Migration and Speciation in UO_2 and UO_{2+x}. Inorg.Chem., 2019, 58 (8), pp.4761-4773. ⟨10.1021/acs.inorgchem.8b03076⟩. ⟨hal-02116819⟩
  • S. Sels, T. Day Goodacre, B.A. Marsh, A. Pastore, W. Ryssens, et al.. Shape staggering of midshell mercury isotopes from in-source laser spectroscopy compared with density-functional-theory and Monte Carlo shell-model calculations. Phys.Rev.C, 2019, 99 (4), pp.044306. ⟨10.1103/PhysRevC.99.044306⟩. ⟨hal-02097388⟩
  • François Lux, Vu Long Tran, Eloise Thomas, Sandrine Dufort, Fabien Rossetti, et al.. AGuIX® from bench to bedside—Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine. British Journal of Radiology, 2019, 92 (1093), pp.20180365. ⟨10.1259/bjr.20180365⟩. ⟨hal-01935540⟩
  • C. Aidala, Y. Akiba, M. Alfred, V. Andrieux, K. Aoki, et al.. Creation of quark–gluon plasma droplets with three distinct geometries. Nature Physics, 2019, 15 (3), pp.214-220. ⟨10.1038/s41567-018-0360-0⟩. ⟨hal-01802043⟩
  • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Analysis of the apparent nuclear modification in peripheral Pb–Pb collisions at 5.02 TeV. Physics Letters B, 2019, 793, pp.420-432. ⟨10.1016/j.physletb.2019.04.047⟩. ⟨hal-01801903⟩

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