Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • A. Astier, L. Ducroux, R. Duffait, Y. Le Coz, M. Meyer, et al.. High spin investigation in ^{193}Pb with EUROGAM 2: coexistence of superdeformed and dipole bands. International Conference on Nuclear structure around the turn of the century, Jun 1996, Crete, Greece. pp.195-196. ⟨in2p3-00000244⟩
  • F. Hannachi, A. Lopez-Martens, A. Korichi, C. Schuck, E. Gueorguieva, et al.. Observation of the single links of the yrast superdeformed band in ^{194}Pb. International Conference on Nuclear structure around the turn of the century, Jun 1996, Crete, Greece. pp.183-184. ⟨in2p3-00005047⟩
  • P. Antilogus. Update on electroweak parameters on the Z. Physics in Collisions 98, Jun 1996, Mexico, Mexico. ⟨in2p3-00022858⟩
  • M. Bedjidian. Upsilon and J/\psi detection with CMS. CMS Heavy Ion Workshop, Jun 1996, Lyon, France. ⟨in2p3-00023076⟩
  • M. Giffon, E. Predazzi, A. Samokhin. Possible C-odd effects in high energy anti-p p and pp elastic scattering at T=0. International Workshop on High Energy Physics HADRONS 96 12, Jun 1996, Novy Svet, Ukraine. ⟨in2p3-00010611⟩
  • A. de Bellefon, L. Berge, I. Berkes, C. Bobin, D. Broszkiewicz, et al.. Status report of the EDELWEISS experiment. Rencontres de Blois 8, Jun 1996, Blois, France. ⟨in2p3-00005251⟩
  • J.-P. Walder. High dynamic range and low power integrated front end design techniques for avalanche photodiode readout. Conference on New Developments in Photodetection, Jun 1996, Beaune, France. pp.266. ⟨in2p3-00007764⟩
  • J. Jagielski, G. Marest, N. Moncoffre. Quantitative analysis of nitride phases determined from CEMS spectra on N^+ implanted Fe samples. European Material Research Society Conference, Jun 1996, Strasbourg, France. pp.575-578. ⟨in2p3-00007576⟩
  • M C. Abreu, C. Alexa, B. Alessandro, J. Astruc, C. Baglin, et al.. J/\psi and \psi ' production in lead-lead collisions at the CERN SPS. International Conference on Particles and Nuclei PANIC'96, May 1996, Williamsburg, United States. pp.419-421. ⟨in2p3-00010759⟩
  • M C. Abreu, C. Alexa, B. Alessandro, J. Astruc, C. Baglin, et al.. Intermediate mass muon pair continuum in Pb-Pb collisions at 158 GeV c. International Conference on Ultra-Relativistic Nucleus-Nucleus Collisions - Quark Matter'96, May 1996, Heidelberg, Germany. pp.331C-341C. ⟨in2p3-00014361⟩

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