Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • B. Farizon, M. Farizon, M.J. Gaillard, R. Genre, E. Gerlic, et al.. Multifragmentation of hydrogen clusters induced by high-energy collisions with fullerenes. International Workshop Collisions Studies Involved Fullerenes, Aug 1996, Stockholm, Sweden. ⟨in2p3-00013443⟩
  • M. Kibler. Wigner-Racah calculus and two-photon spectroscopy of ions in finite symmetry. International School on Theoretical Physics 4, Aug 1996, Zajczkowo, Poland. pp.237-250. ⟨in2p3-00003181⟩
  • W. Wernsdorfer, B. Doudin, D. Mailly, Klaus Hasselbach, A. Benoît, et al.. Nucleation of Magnetization Reversal in Individual Nanosized Nickel Wires. Physical Review Letters, 1996, 77 (9), pp.1873. ⟨hal-01659966⟩
  • M. Kibler. On quadratic and nonquadratic forms: application to R^{2m} \rightarrow R^{2m-n} nonbijective transformations. Symposium on Symmetries in Science 9, Aug 1996, Bregenz, Austria. pp.354. ⟨in2p3-00005049⟩
  • M. Giffon, A. Samokhin. C-odd effects in the diffractive domain. International Conference on High Energy Physics 28 HICHEP'96, Jul 1996, Warsaw, Poland. ⟨in2p3-00010614⟩
  • J.-P. Martin. Higgs particles searches at LEP. International Conference on High Energy Physics - ICHEP'96 28, Jul 1996, Warsaw, Poland. ⟨in2p3-00022859⟩
  • P. Petiau, M C. Abreu, B. Alessandro, C. Alexa, J. Astruc, et al.. Anomalous J/\psi production in Pb-Pb collisions at 158 GeV per nucleon. International Conference on High Energy Physics 28 ICHEP'96, Jul 1996, Warsaw, Poland. pp.999-1004. ⟨in2p3-00000869⟩
  • M. Farizon, B. Farizon, M.J. Gaillard, R. Genre, S. Louc. Multifragmentation d'agregats induite par collisions a haute vitesse. Colloque sur la Dynamique des Ions des Atomes et des Molecules - DIAM 4 4, Jul 1996, Bourges, France. ⟨in2p3-00013444⟩
  • V. Chazal. EDELWEISS experiment and neutron background measurements in the underground laboratory of Modane. Rencontres de Moriond, Jul 1996, Moriond, France. ⟨in2p3-00005627⟩
  • S. Bouneau, F. Azaiez, J. Duprat, I. Deloncle, M.G. Porquet, et al.. New results on the superdeformed ^{196}Pb nucleus: decay of the excited bands to the yrast band. International Conference on Nuclear structure around the turn of the century, Jun 1996, Crete, Greece. pp.179-180. ⟨in2p3-00000246⟩

Powered by HAL logo