Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • G. Chanfray. Mesons dans la matiere dense. Journees SFP, Nov 1996, Orsay, France. ⟨in2p3-00023066⟩
  • Z. Vidovic, A. Billebaud, M. Fallavier, R. Kirsch, J.-C. Poizat, et al.. Statistique de l'emission electronique secondaire de surfaces de carbone amorphe sous l'impact d'ions H^+_2 et H^+_3 rapides (0.25-1.0 MeV/u). Reunion Annuelle du GDR-CNRS 1021 Agregats, Nov 1996, Toulouse, France. ⟨in2p3-00023065⟩
  • N. Moncoffre, A. Chevarier, N. Chevarier, N. Millard-Pinard. Study of radioactive fission product migration in high level waste storage materials by means of ion implantation. International Workshop on Reasearch with Fission Fragments, Oct 1996, Benediktbeuern, Germany. pp.1-5. ⟨in2p3-00012079⟩
  • L. Mirabito. Recent results with two variants of micro-gap chambers. Wokshop on MSGC and TRT for LHC Experiment, Oct 1996, Cracovie, Poland. ⟨in2p3-00022856⟩
  • H. Allali, O. Debré, J.-P. Thomas, M. Petit-Ramel, E.H. Sayouty, et al.. Analytical investigations of water sediment exchanges contribution of the HSF-SIMS technique. International Symposium on Environmental Pollution and Impact Assessment, Oct 1996, Mohammedia, Morocco. ⟨in2p3-00022857⟩
  • B. Borderie, F. Gulminelli, M R. Rivet, D. Dore, A. Chbihi, et al.. Thermodynamical properties and deexcitation of sources involved in collisions between light nuclei around 100 AMeV incident energy. International Research Workshop on Heavy-ion Physics at Low, Intermediate and Relativistic Energies using 4\pi Detectors, Oct 1996, Poiana Brasov, Romania. pp.96-107. ⟨in2p3-00007485⟩
  • Y. Benhammou. Test beam results of lead tungstate matrices. International Conference on Advanced Technology and Particle Physics : ICATPP-5 5, Oct 1996, Como, Italy. pp.493-497. ⟨in2p3-00007486⟩
  • J.-D. Durand. Mesures du melange effectif et des asymetries des quarks b et c dans les desintegrations semileptoniques en electrons et en muons. Physique des Hautes Energies - Expérience [hep-ex]. Université Claude Bernard - Lyon I, 1996. Français. ⟨NNT : ⟩. ⟨in2p3-00002742⟩
  • R. Dayras, G. Auger, C O. Bacri, A. Benkirane, J. Benlliure, et al.. Multifragment production in heavy ion induced reactions at intermediate energy. Colloque Franco-Japonais : Frontier and perspective of Nuclear Science, Sep 1996, Dogashima, Japan. pp.1-12. ⟨in2p3-00010754⟩
  • P. Pangaud, F. Anstotz, Y. Hu, J. Michel, D. Lachatre. Front-end read out electronic developemnet for microstrip detectors in CMS : FILTRES. Workshop on Electronics for LHC Experiments 2, Sep 1996, Baltonfuered, Germany. ⟨in2p3-00023075⟩

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