Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • O. Debré, B. Nsouli, J.-P. Thomas, Isabelle Stevenson, D. Colombini, et al.. Gamma irradiation-induced modifications of polymers found in nuclear waste embedding processes - Part I : The epoxy/amine resin. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1997, 131, pp.313-320. ⟨in2p3-00007490⟩
  • D.G. Blair, J.-M. Mackowski, P. Ganau, C. Michel, L. Pinard. Development of low-loss sapphire mirrors. Applied optics, 1997, 36, pp.397-403. ⟨in2p3-00000263⟩
  • L. Dognin. Etude de l'uniformite des multicouches dielectriques des optiques de Virgo par simulation numerique. Cosmology and Extra-Galactic Astrophysics [astro-ph.CO]. Université Claude Bernard - Lyon I, 1997. English. ⟨NNT : ⟩. ⟨in2p3-00000145⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, I. Ajinenko, et al.. Measurement of B^0_d - \overline B^0_d oscillations. Zeitschrift für Physik. C, Particles and Fields, 1997, 76, pp.579-598. ⟨10.1007/s002880050582⟩. ⟨in2p3-00001144⟩
  • P. Abreu, W. Adam, T. Adye, I. Ajinenko, G D. Alekseev, et al.. Search for Lepton Flavour Number violating Z^0-Decays. Zeitschrift für Physik. C, Particles and Fields, 1997, 73, pp.243-251. ⟨10.1007/s002880050313⟩. ⟨in2p3-00003448⟩
  • R. Rapp, G. Chanfray, J. Wambach. \rho Meson Propagation and Dilepton Enhancement in Hot Hadronic Matter. Nuclear Physics A, 1997, 617, pp.472-476. ⟨in2p3-00000037⟩
  • Micheline Draye, Bilal Nsouli, Hakim Allali, Jean-Paul Thomas. Gamma-ray-induced modifications of the chemical structure of an ion exchange resin. Polymer Degradation and Stability, 1997, 56, pp.157-167. ⟨10.1016/S0141-3910(96)00176-0⟩. ⟨hal-00006561⟩
  • H. Allali, M. Ben Embarek, O. Debré, B. Nsouli, A. Oladipo, et al.. An HSF-SIMS investigation of the prephosphatation contribution to the phosphatation process of silicion steel surface. Rapid Communications in Mass Spectrometry, 1997, 11, pp.1377. ⟨in2p3-00007493⟩
  • M. Acciarri, O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, et al.. Measurements of Mass, Width and Gauge Couplings of the W Boson at LEP. Physics Letters B, 1997, 413, pp.176-190. ⟨10.1016/S0370-2693(97)01082-4⟩. ⟨in2p3-00023163⟩
  • M. Acciarri, O. Adriani, M. Aguilar-Benitez, S. Ahlen, B. Alpat, et al.. Production of Single W Bosons at LEP. Physics Letters B, 1997, 403, pp.168-176. ⟨in2p3-00000069⟩

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