Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • P. Abreu, W. Adam, T. Adye, G D. Alekseev, R. Alemany, et al.. Measurement of the spin density matrix for the \rho^0, SK^{*0}(892) and \phi produced in Z^0 Decays. Physics Letters B, 1997, 406, pp.271-286. ⟨10.1016/S0370-2693(97)00758-2⟩. ⟨in2p3-00003403⟩
  • P. Abreu, W. Adam, T. Adye, I. Ajinenko, G D. Alekseev, et al.. Measurement of the Multiplicity of Gluons Splitting to Bottom Quark Pairs in Hadronic Z^0 Decays. Physics Letters B, 1997, 405, pp.202-214. ⟨10.1016/S0370-2693(97)00608-4⟩. ⟨in2p3-00003413⟩
  • D. Bertini. Mesure de la production du baryon charme \lambda_c et etude des desintegrations semi-leptoniques du baryon \lambda_c par l'experience DELPHI au LEP. High Energy Physics - Experiment [hep-ex]. Université Claude Bernard - Lyon I, 1997. English. ⟨NNT : ⟩. ⟨in2p3-00003396⟩
  • Isabelle Stevenson, O. Debré, J.-P. Thomas. Stability under \gamma irradiation aging of an epoxy/amine resin embedding simulated nuclear waste: critical assessment of the techniques investigating chemical structure (IR and SIM spectroscopies) and bulk properties (DMA DSC). Macromolecular Symposia, 1997, 219, pp.213. ⟨in2p3-00007492⟩
  • M. Acciarri, O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, et al.. \Upsilon production in Z Decays. Physics Letters B, 1997, 413, pp.167-175. ⟨in2p3-00000220⟩
  • J.Y. Vinet, V. Brisson, S. Braccini, I. Ferrante, L. Pinard, et al.. Scattered light noise in gravitational wave interferometric detectors: a statistical approach. Physical Review D, 1997, 56, pp.6085-6095. ⟨in2p3-00000213⟩
  • P. Desgrolard, J. Kontros, a I. Lengyel, E S. Martynov. Local nuclear slope and curvature in high energy pp and \overline{p}p elastic scattering. Il Nuovo Cimento A, 1997, 110, pp.615-630. ⟨in2p3-00000042⟩
  • M C. Abreu, B. Alessandro, C. Alexa, J. Astruc, C. Baglin, et al.. Anomalous J/\psi suppression in Pb-Pb interactions at 158 GeV per nucleon. Physics Letters B, 1997, 410, pp.337-343. ⟨in2p3-00000868⟩
  • S. Leoni, B. Herskind, T. Dossing, A. Atac, I.G. Bearden, et al.. Four independent decay properties in the super-deformed well of ^{143}Eu. Physics Letters B, 1997, 409, pp.71-76. ⟨in2p3-00000270⟩
  • O. Debré, B. Nsouli, J.-P. Thomas, Isabelle Stevenson, D. Colombini, et al.. Gamma irradiation-induced modifications of polymers found in nuclear waste embedding processes - Part I : The epoxy/amine resin. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 1997, 131, pp.313-320. ⟨in2p3-00007490⟩

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