Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • D.G. Blair, J.-M. Mackowski, P. Ganau, C. Michel, L. Pinard. Development of low-loss sapphire mirrors. Applied optics, 1997, 36, pp.397-403. ⟨in2p3-00000263⟩
  • S. Leoni, B. Herskind, T. Dossing, A. Atac, I.G. Bearden, et al.. Four independent decay properties in the super-deformed well of ^{143}Eu. Physics Letters B, 1997, 409, pp.71-76. ⟨in2p3-00000270⟩
  • L. Dognin. Etude de l'uniformite des multicouches dielectriques des optiques de Virgo par simulation numerique. Cosmology and Extra-Galactic Astrophysics [astro-ph.CO]. Université Claude Bernard - Lyon I, 1997. English. ⟨NNT : ⟩. ⟨in2p3-00000145⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, G D. Alekseev, et al.. Observation of charge ordering in particle production in hadronic Z^0 decay. Physics Letters B, 1997, 407, pp.174-184. ⟨10.1016/S0370-2693(97)11783-X⟩. ⟨in2p3-00003402⟩
  • P. Abreu, W. Adam, T. Adye, I. Ajinenko, G D. Alekseev, et al.. Measurement of Event Shape and Inclusive Distributions at \sqrt{s} = 130 and 136 GeV. Zeitschrift für Physik. C, Particles and Fields, 1997, 73, pp.229-242. ⟨10.1007/s002880050312⟩. ⟨in2p3-00001149⟩
  • P. Abreu, W. Adam, T. Adye, I. Ajinenko, G D. Alekseev, et al.. Identified particles in quark and gluon jets. Physics Letters B, 1997, 401, pp.118-130. ⟨10.1016/S0370-2693(97)00405-X⟩. ⟨in2p3-00001140⟩
  • M. Kibler, L.G. Mardoyan, G.S. Pogosyan. A generalized oscillator system. Turkish Journal of Physics, 1997, 21, pp.425-436. ⟨in2p3-00008114⟩
  • X. Artru, J. Czyzewski, H. Yabuki. Single spin asymmetry in inclusive pion production, Collins effect and the string model. Zeitschrift für Physik. C, Particles and Fields, 1997, 73, pp.527-534. ⟨in2p3-00000115⟩
  • S. Andriamonje, K. Beckert, M. Chevallier, C. Cohen, D. Dauvergne, et al.. Channeling experiment with a cooled and decelerate H-like gold ion beam extracted from a storage ring. Journal of Physics B: Atomic, Molecular and Optical Physics, 1997, 30, pp.5099-5108. ⟨in2p3-00014301⟩
  • H-T. Prinz, D. Dauvergne, S. Andriamonje, K. Beckert, M. Chevallier, et al.. Probing a cooled beam of decelerated highly-charged heavy ions extracted out of the ESR by a channeling experiment. Hyperfine Interactions, 1997, 108, pp.325-332. ⟨in2p3-00001128⟩

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