Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • R. Bougault, J.P. Wieleczko, M. d'Agostino, W.A. Friedman, F. Gulminelli, et al.. A possible scenario for the time dependence of the multifragmentation process in Xe+Sn collisions (an explanation of the 3He puzzle). International Winter Meeting on Nuclear Physics 35, Feb 1997, Bormio, Italy. pp.251-275. ⟨in2p3-00023111⟩
  • R. Rapp, G. Chanfray, J. Wambach. Low-Mass e^+e^- Pairs from in-Medium \rho Meson Propagation. International Workshop on Gross Properties of Nuclei and Nuclear Excitations: QCD Phase Transitions 25, Jan 1997, Hirschegg, Austria. pp.192-200. ⟨in2p3-00003415⟩
  • M. Gonin, M C. Abreu, C. Alexa, B. Alessandro, J. Astruc, et al.. Anomaly in charmonium suppression in Pb+Pb collisions. International Workshop on Gross Properties of Nuclei and Nuclear Excitations 25, Jan 1997, Hirschegg, Austria. pp.254-268. ⟨in2p3-00007651⟩
  • M. Acciarri, O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, et al.. Hard-photon production at \sqrt{s} = 161 and 172 GeV at LEP.. Physics Letters B, 1997, 413, pp.159-166. ⟨10.1016/S0370-2693(97)01081-2⟩. ⟨in2p3-00000205⟩
  • M. Acciarri, O. Adriani, M. Aguilar-Benitez, S. Ahlen, B. Alpat, et al.. Search for Exclusive B Decays to J and \eta or \pi^{0} with the L3 Detector. Physics Letters B, 1997, 391, pp.481-490. ⟨10.1016/S0370-2693(96)01584-5⟩. ⟨in2p3-00000257⟩
  • M. Acciarri, O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, et al.. Measurement of W-pair cross sections in e^+ e^- interactions at \sqrt{s} = 172 GeV and W decay branching fractions. Physics Letters B, 1997, 407, pp.419-431. ⟨10.1016/S0370-2693(97)00802-2⟩. ⟨in2p3-00000060⟩
  • M. Acciarri, O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, et al.. Inclusive J, \psi' and \chi_c Production in Hadronic Z Decays. Physics Letters B, 1997, 407, pp.351-360. ⟨in2p3-00000259⟩
  • C. Antoine, B. Bonin, H. Safa, B. Berthier, E. Tessier, et al.. Evidence of preferential diffusion and segregation of impurities at grain boundaries in very pure niobium used for radiofrequency cavities. Journal of Applied Physics, 1997, 81, pp.1677-1682. ⟨in2p3-00007489⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, G D. Alekseev, et al.. A Combination of preliminary Electroweak Measurements and Constraints on the Standard Model. 1997, pp.1-64. ⟨in2p3-00014483⟩
  • P. Desgrolard, a I. Lengyel, E S. Martynov. Nonlinearities and Pomeron Nonfactorizability in Conventional Diffraction. Il Nuovo Cimento A, 1997, 110, pp.254-266. ⟨in2p3-00000044⟩

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