Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • P. Antilogus. \sin^2 \theta^{lep}_{eff} from hadronic final states. Workshop on Weak interactions and Neutrinos WIN 97, Jun 1997, Capri, Italy. pp.55-58. ⟨in2p3-00003393⟩
  • A. Chevarier, N. Chevarier, J.-C. Duclot, N. Millard-Pinard, N. Moncoffre. Utilisation de faisceaux d'ions radioactifs dans le cadre du GDR Practis. Colloque GANIL 11, Jun 1997, Seignosse, pp.6. ⟨in2p3-00002402⟩
  • S. Perriès. Calculs GCM des corrélations octopolaires des noyaux superdéformés de masse A \sim 190. Rencontre de Gif de la Communaute EUROBALL, Jun 1997, Gif-Sur-Yvette, France. ⟨in2p3-00004714⟩
  • B. Borderie, F. Gulminelli, M F. Rivet, L. Tassan-Got, M. Assenard, et al.. Thermodynamical equilibrium for nuclear matter produced in heavy ion collisions around 100 AMeV?. International Conference on Nuclear Reaction Mechanisms 8, Jun 1997, Varenna, Italy. pp.239-248. ⟨in2p3-00003708⟩
  • T. Von Egidy, U. Koester, E. Steichele, D. Habs, O. Kester, et al.. Experiments with accelerated fission fragments. International Conference on Nuclear Reaction Mechanisms 8, Jun 1997, Varenna, Italy. pp.454-464. ⟨in2p3-00000388⟩
  • M C. Abreu, B. Alessandro, C. Alexa, J. Astruc, C. Baglin, et al.. J/\psi and \psi ' production in lead-lead collisions at 158 A GeV/c. International Conference on Nuclear Reaction Mechanisms 8, Jun 1997, Varenna, Italy. pp.513-522. ⟨in2p3-00000046⟩
  • M. Morjean, M. Chevallier, C. Cohen, D. Dauvergne, J. Dural, et al.. Fission lifetime measured by the blocking technique as a function of excitation energy in the 24 A.MeV ^{238}U + ^{28}Si reaction. Sixth International Conference on Nucleus-Nucleus Collisions, Jun 1997, Gatlinburg, United States. pp.200c-208c. ⟨in2p3-00003441⟩
  • J. Meyer. Forces effectives loin de la stabilite. Colloque Ganil 11, Jun 1997, Seignosse, France. ⟨in2p3-00004713⟩
  • N. Chevarier, N. Moncoffre. Utilisation des faisceaux radioactifs pour l'etude des materiaux de stockage. Colloque Ganil 11, Jun 1997, Seignosse, France. ⟨in2p3-00004711⟩
  • D. Guinet. Emission dynamique de mi rapidite et emission de preequilibre. Colloque Ganil 11, Jun 1997, Seignosse, France. ⟨in2p3-00004712⟩

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