Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of B^0_\mathrm{s} meson production in pp and PbPb collisions at \sqrt{s_\mathrm{NN}} = 5.02 TeV. Physics Letters B, 2019, 796, pp.168-190. ⟨10.1016/j.physletb.2019.07.014⟩. ⟨hal-01902956⟩
  • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, et al.. Multiplicity dependence of (anti-)deuteron production in pp collisions at \sqrt{s} = 7 TeV. Physics Letters B, 2019, 794, pp.50-63. ⟨10.1016/j.physletb.2019.05.028⟩. ⟨hal-02066929⟩
  • Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. Charged-particle production as a function of multiplicity and transverse spherocity in pp collisions at \sqrt{s} =5.02 and 13 TeV. European Physical Journal C: Particles and Fields, 2019, 79 (10), pp.857. ⟨10.1140/epjc/s10052-019-7350-y⟩. ⟨hal-02148291⟩
  • Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. Measurement of \Upsilon(1{\rm S}) elliptic flow at forward rapidity in Pb-Pb collisions at \sqrt{s_{\rm{NN}}}=5.02 TeV. Physical Review Letters, 2019, 123 (19), pp.192301. ⟨10.1103/PhysRevLett.123.192301⟩. ⟨hal-02193942⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for a W' boson decaying to a \tau lepton and a neutrino in proton-proton collisions at \sqrt{s} = 13 TeV. Phys.Lett.B, 2019, 792, pp.107-131. ⟨10.1016/j.physletb.2019.01.069⟩. ⟨hal-01862006⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for rare decays of Z and Higgs bosons to J/\psi and a photon in proton-proton collisions at \sqrt{s} = 13 TeV. Eur.Phys.J.C, 2019, 79 (2), pp.94. ⟨10.1140/epjc/s10052-019-6562-5⟩. ⟨hal-01914603⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Observation of Single Top Quark Production in Association with a Z Boson in Proton-Proton Collisions at \sqrt {s} =13 TeV. Phys.Rev.Lett., 2019, 122 (13), pp.132003. ⟨10.1103/PhysRevLett.122.132003⟩. ⟨hal-01974833⟩
  • Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for supersymmetric partners of electrons and muons in proton-proton collisions at \sqrt{s}= 13 TeV. Phys.Lett.B, 2019, 790, pp.140-166. ⟨10.1016/j.physletb.2019.01.005⟩. ⟨hal-01833709⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for anomalous electroweak production of vector boson pairs in association with two jets in proton-proton collisions at 13 TeV. Phys.Lett.B, 2019, 798, pp.134985. ⟨10.1016/j.physletb.2019.134985⟩. ⟨hal-02148297⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for dark matter in events with a leptoquark and missing transverse momentum in proton-proton collisions at 13 TeV. Phys.Lett.B, 2019, 795, pp.76-99. ⟨10.1016/j.physletb.2019.05.046⟩. ⟨hal-01953194⟩

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