Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    545 documents

    • D. Brichart-Vernos, M.-T. Aloy, J. Sidi-Boumedine, G. Ollier, O. Tillement, et al.. Evaluation de l'effet sensibilisant des nanoparticules AGuIX associees a une irradiation photonique dans un modele de chondrosarcome. GDR MI2B - Nanoparticules en radiotherapie et radiobiologie, Nov 2022, Clermont -Ferrand, France. ⟨in2p3-04956373⟩
    • Oreste Allegrini. Caractérisation de détecteurs pour des systèmes de monitorage des faisceaux d'ions en hadronthérapie. Physique Médicale [physics.med-ph]. Université Claude Bernard - Lyon I, 2022. Français. ⟨NNT : 2022LYO10110⟩. ⟨tel-04458930⟩
    • M.E. Alcover-Avila, V. Levrague, M. Pedrosa, R. Delorme, E. Testa, et al.. Prediction de la survie cellulaire aux irradiations avec des ions de basse energie:integration 'effets hors noyau dans le modele biophysique NanOx. 1er Congres de la Société Française de Biologie des Radiations, Nov 2022, Agay -Saint Raphael, France. ⟨in2p3-04954481⟩
    • A.-S. Wozny, G. Alphonse, S. Sebaï, O. Lole, M. Beuve, et al.. Etude de la proteostate en réponse à une irradiation photonique et par ions carbone. 1er Congrès de la Société Française de Biologie des Radiations, Nov 2022, Agays-Saint Raphael, France. ⟨in2p3-04956285⟩
    • G. Alphonse, P. Philouze, A. Gautier, A. Lauret, C. Melsys, et al.. Biomarqueurs prédictifs de la réponse thérapeutique chez des patients atteints d'un carcinome épidermoïde avancé de l'oropharynx. 1er Congrès de la Société Française de Biologie des Radiations, Nov 2022, Agay-Saint Raphael, France. ⟨in2p3-04956300⟩
    • M. Soumboundou, C. Maesys, I. Thiam, M. Gadji, M. Dem, et al.. Etude de biomarqueurs de réponse à la radiothérapie sur des biopsies de cancer du col de l'utérus chez des femmes sénégalaises. 1er Congrès de la Société Française de Biologie des Radiations, Nov 2022, Agay -Saint Raphael, France. ⟨in2p3-04956346⟩
    • C. Rodriguez-Lafrasse. Spécificités moléculaires de la réponse tumorale aux ions carbone: le paradigme du bombardier furtif. 1er Congrès de la Société Française de Biologie des Radiations, Nov 2022, Agay-Saint Raphael, France. ⟨in2p3-04955889⟩
    • M.-T. Aloy, D. Brichart-Vernos, J. Sidi-Boumedine, A. Gautier, P. Rocchi, et al.. Preuve de concept de l'effet radiosensibilisant et antimétastatique des nanoparticules AGuIX et CuPRIX dans différents modèles cellulaires et précliniques. 1er Congrès de la Société Française de Biologie des Radiations, Nov 2022, Agay -Saint Raphael, France. ⟨in2p3-04956333⟩
    • Feriel Khellaf, Nils Krah, Jean Michel Létang, Simon Rit. Projection deconvolution for proton CT using the spatially variant path uncertainty. IEEE Transactions on Radiation and Plasma Medical Sciences, 2022, 6 (8), pp.847-858. ⟨10.1109/TRPMS.2022.3167334⟩. ⟨hal-03656408⟩
    • V. Levrague, M.E. Alcocer-Ávila, L. Maigne, M. Beuve, E. Testa, et al.. Impact of intracellular radionuclide distribution in Targeted Alpha Therapy : a Monte-Carlo biophysical study in 3D multicellular model. IV Geant4 International User Conference at the physics-medicine-biology frontier, Geant4 collaboration, Oct 2022, Naples, Italy. ⟨hal-04305622⟩

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