Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

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    8790 documents

    • David Sarrut, Ane Etxebeste, Enrique Muñoz, Nils Krah, J.-M. Letang. Artificial Intelligence for Monte Carlo Simulation in Medical Physics. Frontiers in Physics, 2021, 9, ⟨10.3389/fphy.2021.738112⟩. ⟨hal-03409138⟩
    • M. Borja-Lloret, A. Etxebeste, G. Llosá, Enrique Muñoz, Ana Ros, et al.. Efficiency enhancement studies in a scintillator-based Compton camera for hadrontherapy. IEEE Nuclear Science Symposium and Medical Imaging Conference (IEEE NSS MIC) 2021, Oct 2021, Virtual Yokohama, Japan, Oct 2021, Yokohama (virtual), Japan. ⟨hal-03473025⟩
    • Ane Etxebeste, Enrique Muñoz, Denis Dauvergne, J M Letang, M. Borja-Lloret, et al.. Comparison of efficiency and activity recovery coefficients of Compton and Anger cameras in Nuclear Medicine. IEEE Nuclear Science Symposium and Medical Imaging Conference (IEEE NSS MIC) 2021, Oct 2021, Virtual Yokohama, Japan, Oct 2021, Yokohama (virtual), Japan. ⟨hal-03473005⟩
    • Magdalena Garbacz, Francesco Giuseppe Cordoni, Marco Durante, Jan Gajewski, Kamil Kisielewicz, et al.. Study of relationship between dose, LET and the risk of brain necrosis after proton therapy for skull base tumors. Radiotherapy & Oncology, 2021, 163, pp.143-149. ⟨10.1016/j.radonc.2021.08.015⟩. ⟨hal-03346790⟩
    • Thomas Kosc. Kinematic search for tau neutrino appearance in the DUNE experiment. Nuclear Experiment [nucl-ex]. UniversitĂ© de Lyon, 2021. English. ⟨NNT : 2021LYSE1170⟩. ⟨tel-03544045⟩
    • Amalia Jacquot, CĂ©line Chauleur, Anne-Sophie Russel-Robillard, Fabien Tinquaut, Sandrine Sotton, et al.. MRI accuracy and interobserver agreement in locally advanced cervix carcinoma. British Journal of Radiology, 2021, 94 (1125), ⟨10.1259/bjr.20210197⟩. ⟨hal-04826687⟩
    • G. Muggiolu, S. Libert, B. Treillard, G. Alfonse, P. Philouze, et al.. PO-1929 Identification of DNA repair-based biomarkers related to treatment outcome in head and neck cancers. ESTRO, Aug 2021, Madrid, Spain. pp.S1643-S1644, ⟨10.1016/s0167-8140(21)08380-8⟩. ⟨hal-03450014⟩
    • Anne-Sophie Wozny, Arnaud Gauthier, Gersende Alphonse, CĂ©line MalĂ©sys, Virginie Varoclier, et al.. Involvement of HIF-1α in the Detection, Signaling, and Repair of DNA Double-Strand Breaks after Photon and Carbon-Ion Irradiation. Cancers, 2021, 13 (15), pp.3833. ⟨10.3390/cancers13153833⟩. ⟨hal-03326508⟩
    • Shahram Vatani. UV Completion of Composite Higgs Models. Nuclear Theory [nucl-th]. UniversitĂ© de Lyon, 2021. English. ⟨NNT : 2021LYSE1155⟩. ⟨tel-03497325⟩
    • T. Salagnac, J. Billard, J. Colas, D. Chaize, M. de Jesus, et al.. Optimization and performance of the CryoCube detector for the future RICOCHET low-energy neutrino experiment. 19th International Workshop on Low Temperature Detectors, Jul 2021, Online Conference, United States. pp.398-406, ⟨10.1007/s10909-023-02960-8⟩. ⟨hal-03472044⟩

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