Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • O. Drapier. Production du J/\psi dans les collisions Pb-Pb derniers resultats de l'experience NA50. Journees Thematiques de l'IPN Orsay, Sep 1997, Orsay, France. ⟨in2p3-00023077⟩
  • G. Chanfray. Mesons vecteurs dans la matiere dense et chaude. Journees Thematiques de l'IPN Orsay, Sep 1997, Orsay, France. ⟨in2p3-00023078⟩
  • M. Morjean, M. Chevallier, C. Cohen, D. Dauvergne, J. Dural, et al.. A direct determination of fission lifetimes as a function of excitation energy by the blocking technique. International School-Seminar on Heavy Ion Physics 6, Sep 1997, Dubna, Russia. pp.683-687. ⟨in2p3-00014318⟩
  • M C. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, J. Astruc, et al.. Recent results on anomalous J/\psi suppression in PbPb collisions at 158 GeV/c. International Workshop on Progress in Heavy Quark Physics 4, Sep 1997, Rostock, Germany. pp.1-32. ⟨in2p3-00000265⟩
  • M. Kibler, M. Daoud. An Alternative Basis for the Wigner-Racah Algebra of the Group SU 2. International Conference on Quantum Groups Deformations and Contractions, Sep 1997, Istanbul, Turkey. pp.12. ⟨in2p3-00003440⟩
  • X. Artru. Resolution power of optical transition radiation theoretical considerations. Conference RREPS (Radiation Relativistic Electrons in Periodical Structures) 3, Sep 1997, Tomsk, Russia. ⟨in2p3-00022850⟩
  • P. Giubellino, M C. Abreu, B. Alessandro, C. Alexa, R. Arnaldi, et al.. J/\psi suppression. International symposium on multiparticle dynamics 27, Sep 1997, Frascati, Italy. pp.279-286. ⟨in2p3-00003492⟩
  • S. Perriès. Decroissance de la bande hautement deformee yrast de ^{136}Nd intensite experimentale de l'appariement dans le second puits. Ecole Internationale Joliot-Curie de Physique Nucleaire, Sep 1997, Maubuisson, France. ⟨in2p3-00023079⟩
  • L. Bergé, I. Berkes, B. Chambon, M. Chapellier, G. Chardin, et al.. Status of the EDELWEISS Experiment. International Workshop on Topics in Astroparticle and Underground Physics (TAUP 97) 5, Sep 1997, Gran Sasso, Italy. pp.69-73. ⟨in2p3-00003429⟩
  • S. Gourmelen. 2-dimensional (super) conformal field theory and W-algebras. International School of Subnuclear Physics - Highlights 50 years later 35, Sep 1997, Erice, Italy. ⟨in2p3-00022852⟩

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