Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. Acciarri, O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, et al.. Photon structure functions and azimuthal correlations of lepton pairs in tagged gamma gamma collisions. Physics Letters B, 1998, 438, pp.363-378. ⟨10.1016/S0370-2693(98)01162-9⟩. ⟨in2p3-00000108⟩
  • C. Gautherin, M. Houry, W. Korten, Y. Le Coz, R. Lucas, et al.. New isomeric states in ^{152,154,156}Nd produced by spontaneous fission of ^{252}Cf. The European physical journal. A, Hadrons and Nuclei, 1998, 1, pp.391-397. ⟨in2p3-00003427⟩
  • M. Acciarri, O. Adriani, M. Aguilar Benitez, S. Ahlen, J. Alcaraz, et al.. Search for the standard model Higgs boson in e^+ e^- interactions at \sqrt{s}=183 GeV. Physics Letters B, 1998, 431, pp.437-450. ⟨10.1016/S0370-2693(97)01033-2⟩. ⟨in2p3-00000109⟩
  • M. Acciarri, O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, et al.. Test of CP Invariance in Z \to \mu^+\mu^-\gamma decay. Physics Letters B, 1998, 436, pp.428-436. ⟨10.1016/S0370-2693(98)00965-4⟩. ⟨in2p3-00023167⟩
  • M F. Rivet, C O. Bacri, B. Borderie, J.D. Frankland, M. Assenard, et al.. Independence of fragment charge distributions of the size of heavy multifragmenting sources. Physics Letters B, 1998, 430, pp.217-222. ⟨10.1016/S0370-2693(98)00525-5⟩. ⟨in2p3-00000038⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, T. Aldeweireld, et al.. A Search for Heavy Stable and Long-Lived Squarks and Sleptons in e^+ e^- Collisions at Energies from 130 to 183 GeV. Physics Letters B, 1998, 444, pp.491-502. ⟨10.1016/S0370-2693(98)01443-9⟩. ⟨in2p3-00001121⟩
  • B. Roussiere, P. Kilcher, A. Wojtasiewicz, J. Genevey, A. Gizon, et al.. Isomeric M3 transitions in ^{183}Pt and ^{181}Os. Nuclear Physics A, 1998, 643, pp.331-346. ⟨10.1016/S0375-9474(98)00571-5⟩. ⟨in2p3-00007503⟩
  • P. Abreu, W. Adam, T. Adye, I. Ajinenko, G D. Alekseev, et al.. Charged Particle Multiplicity in e^+ e^- \rightarrow q \overline{q} events at 161 and 172 GeV and from the Decay of the W Boson. Physics Letters B, 1998, 416, pp.233-246. ⟨10.1016/S0370-2693(97)01248-3⟩. ⟨in2p3-00001142⟩
  • M C. Abreu, C. Baglin, A. Baldit, M. Bedjidian, P. Bordalo, et al.. Charmonia production in 450 GeV/c proton induced reactions. Physics Letters B, 1998, 444, pp.516-522. ⟨10.1016/S0370-2693(98)01398-7⟩. ⟨in2p3-00000219⟩
  • M. Oinonen, R. Béraud, G. Canchel, E. Chabanat, P. Dendooven, et al.. Production of refractory elements close to the Z = N line using the ion-guide technique. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1998, 416, pp.485-492. ⟨in2p3-00003453⟩

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