Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • A. Benslama, A. Metatla, A. Bachkhaznadji, S.R. Zouzou, A. Krikeb, et al.. Optimized lower bound on four-body hamiltonians. Few-Body Systems, 1998, 24, pp.39-54. ⟨10.1007/s006010050075⟩. ⟨in2p3-00000216⟩
  • M. Acciarri, O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, et al.. Study of anomalous ZZ\gamma and Z\gamma\gamma couplings at LEP. Physics Letters B, 1998, 436, pp.187-198. ⟨10.1016/S0370-2693(98)00883-1⟩. ⟨in2p3-00000016⟩
  • P. Rullhusen, X. Artru, P. Dhez. Novel radiation sources using relativistic electrons - From infrared to X-rays. World Scientific, pp.1-202, 1998, Series on Synchrotron Radiation Techniques and Applications. ⟨in2p3-00000001⟩
  • P. Dendooven, R. Béraud, E. Chabanat, A. Emsallem, A. Honkanen, et al.. Improved ion guide for heavy-ion fusion-evaporation reactions. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1998, 408, pp.530-534. ⟨in2p3-00003442⟩
  • S. Katsanevas, P. Morawitz. SUSYGEN 2.2 : A Monte Carlo Event Generator for MSSM Sparticle Production at e^{+} e^{-} Colliders. Computer Physics Communications, 1998, 112, pp.227-269. ⟨in2p3-00003423⟩
  • M. Acciarri, O. Adriani, M. Aguilar-Benitez, S. Ahlen, J. Alcaraz, et al.. Measurement of the Average Lifetime of b-Hadrons in Z Decays. Physics Letters B, 1998, 416, pp.220-232. ⟨10.1016/S0370-2693(97)01379-8⟩. ⟨in2p3-00000012⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, G D. Alekseev, et al.. Search for charged Higgs bosons in e^+ e^- collisions at \sqrt{s} = 172 GeV. Physics Letters B, 1998, 420, pp.140-156. ⟨10.1016/S0370-2693(97)01543-8⟩. ⟨in2p3-00001118⟩
  • P. Abreu, W. Adam, T. Adye, P. Adzic, I. Ajinenko, et al.. Search for neutral and charged Higgs bosons in e^+ e^- collisions at \sqrt{s}= 161 GeV and 172 GeV. European Physical Journal C: Particles and Fields, 1998, 2, pp.1-37. ⟨10.1007/PL00021558⟩. ⟨in2p3-00003399⟩
  • P. Pawlowski, J. Brzychczyk, A.J. Cole, P. Desesquelles, W. Gawlikowicz, et al.. Intermediate velocity source of intermediate-mass fragments in the ^{40}Ca + ^{40}Ca reaction at E_{lab} = 35 MeV/nucleon. Physical Review C, 1998, 57, pp.1771-1777. ⟨10.1103/PhysRevC.57.1771⟩. ⟨in2p3-00003499⟩
  • F. Gieres, S. Gourmelen. d=2, N=2 Superconformally covariant operators and super W-algebras. Journal of Mathematical Physics, 1998, 39, pp.3453-3475. ⟨in2p3-00002397⟩

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